Severe transaminitis after interferon-ribavirin therapy in HIV/HCV-coinfected patients: influence of a sustained HCV response

Journal of Viral Hepatitis
Firouzé Bani-SadrANRS CO 07-Ribavic Study team

Abstract

Chronic hepatitis C is an independent risk factor for severe drug hepatotoxicity. Successful treatment of chronic hepatitis C may modulate drug hepatotoxicity, as it is associated with a decline in hepatic enzyme release and halts fibrosis progression in HIV/HCV-coinfected patients. The aim of this study was to determine biological and/or clinical determinants of alanine aminotransferase and/or aspartate aminotransferase elevation (>five-fold above the upper limit of normal in patients with normal baseline levels or >3.5-fold increase from baseline in those with increased baseline levels) in a large prospective cohort of HIV/HCV-coinfected patients on HAART who had previously been treated for HCV infection. Median follow-up exceeded five years. Cox proportional hazards models were used. At baseline, 248 patients had been receiving antiretroviral therapy for a mean of 6.3 (± 3.2) years. Seventy-one patients (29%) had a sustained HCV viral response (SVR). During follow-up, 66 patients (26.6%) received a second course of HCV therapy and 29 (44%) of them had an SVR. Severe transaminitis occurred in 64 patients (26%). In multivariate analysis, no SVR (HR 33.33, 95% CI 4.54-222, P = 0.001) and stavudine-based therapy (HR 2.11, 95% CI...Continue Reading

References

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Nov 17, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Firouzé Bani-SadrUNKNOWN ANRS HC02-Ribavic Study Team
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Jan 27, 2007·The Journal of Antimicrobial Chemotherapy·Antonio RiveroJuan A Pineda
Feb 6, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Firouzé Bani-SadrUNKNOWN Viral Hepatitis-HC02-Ribavic Study Team
Jan 22, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Firouzé Bani-SadrUNKNOWN ANRS HC02-Ribavic Study Team
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Aug 17, 2010·Antiviral Therapy·Nicolás MerchanteUNKNOWN Grupo Andaluz para el Estudio de las Hepatitis Víricas de la Sociedad Andaluza de Enfermedades Infecciosas

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Citations

Feb 28, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Giuseppe LapadulaUNKNOWN Italian MASTER Cohort
Nov 20, 2013·Current Opinion in HIV and AIDS·Joanna AllenSanjay Bhagani

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