PMID: 8997465Jan 1, 1997Paper

Severe vaginal bleeding associated with recombinant interferon beta-1B

The Annals of Pharmacotherapy
L A Pakulski, L M DiMarco

Abstract

To report a case of severe vaginal bleeding associated with interferon beta-1b (IFN-beta). A 19-year-old white woman diagnosed with multiple sclerosis was treated with IFN-beta 4 million IU every other day for 1 month. After 1 month, the dosage was increased to 8 million IU. The patient subsequently experienced severe vaginal bleeding. Because her hemoglobin was 3.9 g/dL, she was admitted to the hospital for treatment and observation. IFN-beta was discontinued and she was treated with conjugated estrogens and received 2 units of packed red blood cells. The bleeding ceased and the patient was discharged in stable condition. Menstrual disorders of mild-to-moderate severity were reported during clinical trials with IFN-beta. This is the first case report regarding severe vaginal bleeding probably associated with IFN-beta. The mechanism for development of IFN-beta-related menstrual disorders is unknown. Reports of menstrual disorders associated with recombinant IFN-beta are rare; however, clinicians should be aware that this complication can occur. Should menstrual disorders occur with no other etiologic factors identified, IFN-beta should be discontinued, with improvement expected shortly thereafter.

References

Sep 1, 1987·Acta Neurologica Scandinavica·W H LinssenR Rolland
Feb 1, 1994·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·I R Edwards, C Biriell

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Citations

May 21, 1999·Multiple Sclerosis : Clinical and Laboratory Research·P F Smith, C L Darlington
Feb 15, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·A Bayas, P Rieckmann
Jun 26, 2001·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G NiederwieserP Költringer
Jan 16, 2018·The Journal of International Medical Research·Ülkü Türk BörüMustafa Taşdemir
Mar 17, 2021·Neurología : publicación oficial de la Sociedad Española de Neurología·A Sánchez-SoblecheroJ M García Domínguez

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