Severe veno-occlusive disease after autologous peripheral blood stem cell transplantation for high-grade non-Hodgkin lymphoma: report of a successfully managed case and a literature review of veno-occlusive disease

Clinical Transplantation
Mariangela PalladinoAntonio Grieco

Abstract

Veno-occlusive disease (VOD) of the liver is a severe complication of high-dose chemotherapy and allogeneic or autologous stem cell transplantation with potential fatal outcome. We report a case of severe VOD in a patient with a high-grade B-cell lymphoma. Liver-venule occlusion was confirmed by liver biopsy. Supportive care, fibrinolytic treatment with recombinant tissue plasminogen activator and defibrotide maintenance therapy led to complete resolution of VOD demonstrated at liver biopsy and with a follow-up of 44 months after autologous peripheral blood stem cell transplantation. The literature on VOD has been reviewed.

References

Oct 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L J AyashJ P Eder
Oct 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S I BearmanE D Thomas
May 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H M ShulmanG B McDonald
Jul 23, 2002·Transplantation·Nathalie LassauOlivier Hartmann
Jul 16, 2003·Journal of Ethnopharmacology·Woo Yong OhSun-Mee Lee

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Citations

Nov 28, 2013·Pediatric Blood & Cancer·Francesco De LeonardisNicola Santoro
Aug 14, 2010·Journal of Medical Case Reports·Antonino M Previtera, Rossella Pagani
Apr 23, 2013·Therapeutic Advances in Hematology·Paul G RichardsonRobert Soiffer

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