Abstract
A 79-year-old man without a history of diabetes underwent orchiectomy for prostate cancer. Eight months after the operation, he suffered severe deterioration of visceral fat deposition, fatty liver and diabetes. Treatment for diabetes with canagliflozin and dulaglutide resulted in improvement in his glycemic control, visceral fat and fatty liver. Visceral fat-dominant deposition, which differs from the typical course after androgen deprivation therapy, may have been associated with severe exacerbation of diabetes and fatty liver. Glycemic management with a sodium glucose cotransporter 2 (SGLT2) inhibitor and glucagon-like peptide (GLP)-1 receptor agonist may help improve the glucose metabolism, visceral fat deposition and fatty liver after orchiectomy.
References
Nov 25, 2004·Metabolism: Clinical and Experimental·Makiko InabaSoji Kasayama
Jul 15, 2005·JAMA : the Journal of the American Medical Association·Nima SharifiWilliam L Dahut
Aug 22, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Milena Braga-BasariaShehzad Basaria
Feb 4, 2010·Circulation·Glenn N LevineUNKNOWN American Heart Association Council on Clinical Cardiology and Council on Epidemiology and Prevention, the American Cancer So
May 13, 2010·Diabetes Care·Yumi MatsushitaTetsuya Mizoue
Dec 2, 2010·Clinical Endocrinology·E J HamiltonM Grossmann
Jul 26, 2011·Asian Journal of Andrology·Juan-Jie BoZheng Li
Sep 22, 2011·BJU International·Jenny P NobesRobert W Laing
Mar 1, 2012·PloS One·Jinmi LeeWon-Young Lee
Mar 11, 2015·Obesity·Guadalupe NavarroFranck Mauvais-Jarvis
Sep 18, 2015·The New England Journal of Medicine·Bernard ZinmanUNKNOWN EMPA-REG OUTCOME Investigators
Oct 28, 2015·Prostate Cancer and Prostatic Diseases·K MitsuzukaUNKNOWN Michinoku Urological Cancer Study Group
Nov 27, 2015·Lancet·Matthew James ArmstrongPhilip N Newsome
Jan 1, 2016·JAMA Oncology·Maxine SunQuoc-Dien Trinh
Mar 11, 2016·Scientific Reports·Naoki HaradaRyoichi Yamaji
May 18, 2016·Journal of Diabetes Investigation·Huimin WangJinsheng Zhao
Jun 14, 2016·The New England Journal of Medicine·Steven P MarsoUNKNOWN LEADER Trial Investigators
Jun 25, 2016·European Journal of Endocrinology·Ada S CheungMathis Grossmann
Aug 5, 2017·Expert Opinion on Pharmacotherapy·Akio OhtaYasushi Tanaka
Oct 21, 2017·International Journal of Urology : Official Journal of the Japanese Urological Association·Koji Mitsuzuka, Yoichi Arai
Apr 21, 2018·The Journal of Urology·Philipp GildQuoc-Dien Trinh
Jun 14, 2018·Diabetes Care·Mohammad Shafi KuchayAmbrish Mithal
Dec 17, 2018·EBioMedicine·Andrew WhangHariom Yadav
Jun 14, 2019·Lancet·Hertzel C GersteinUNKNOWN REWIND Investigators