Severe vitamin D deficiency in the first trimester is associated with placental inflammation in high-risk singleton pregnancy

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Qianqian ZhangZhiwei Liu

Abstract

Vitamin D deficiency during pregnancy is a worldwide epidemic. This study aimed to identify whether vitamin D deficiency in early pregnancy is associated with placental inflammation in high-risk pregnancy. This study comprised 23,396 women who provided serum samples in the first trimester for vitamin D analysis from January 2015 to December 2016. Among them, 2648 women with high-risk pregnancy underwent placental pathologic examination. Women were divided into placental inflammation positive (PIP) and placental inflammation negative (PIN) groups based on placental pathology. Multivariate logistic regression was used to evaluate the relationship between vitamin D levels and placental inflammation. We found that severe vitamin D deficiency in early pregnancy was associated with placental inflammation. Maternal vitamin D levels were significantly lower in the PIP group than those in the PIN group (P = 0.025). Compared with the highest quartile of vitamin D levels, risk for placental inflammation was significantly higher in women with extremely low vitamin D levels (<5th percentile; P = 0.012). The effect estimate was slightly decreased but still significant (P = 0.027) after adjusting for maternal age, gestational age at birth, bi...Continue Reading

Citations

May 21, 2020·Nutrients·Bianca Schröder-HeurichFrauke von Versen-Höynck
Jan 22, 2021·Food Science & Nutrition·Zebenay Workneh BitewAyinalem Alemu
May 25, 2021·Clinical Nutrition ESPEN·M Camille HoffmanSharon K Hunter
Dec 2, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Josepheen De Asis-CruzCatherine Limperopoulos

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