Severe Vitamin D Deficiency Is Not Associated with Liver Damage in Morbidly Obese Patients

Obesity Surgery
Rodolphe AntyAlbert Tran

Abstract

A deficiency in vitamin D could be deleterious during chronic liver diseases. However, contradictory data have been published in patients with non-alcoholic fatty liver disease. The aim of the study was to compare the blood level of 25 hydroxy vitamin D (25-OH vitamin D) with the severity of liver lesions, in a large cohort of morbidly obese patients. Three hundred ninety-eight morbidly obese patients had a liver biopsy. The non-alcoholic steatohepatitis (NASH) Clinical Research Network Scoring System Definition and Scores were used. 25-OH vitamin D was evaluated with a Diasorin®Elisa Kit. Logistic regression analyses were performed to obtain predictive factors of the severity of liver histology. 20.6 % of patients had NASH. The stage of fibrosis was F0 12.9 %, F1 57.36 %, F2 25.32 %, F3 (bridging fibrosis) 3.88 %, and F4 (cirrhosis) 0.52 %. The 25-OH vitamin D level inversely correlated to the NAS (r = 0.12 and p = 0.01) and to steatosis (r = 0.14 and p = 0.007); however, it was not associated with the presence of NASH. The level of vitamin D was significantly lower in patients with significant fibrosis compared to those without (15.9 (11.1-23.5) vs 19.6 (13.7-24.7) ng/ml, p = 0.02). There was an inverse correlation between th...Continue Reading

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Citations

Nov 4, 2016·The American Journal of Gastroenterology·Yuval A PatelManal F Abdelmalek
Jun 24, 2017·Journal of Hepatology·Jian-Gao FanVincent Wai-Sun Wong
Jul 3, 2018·Minerva medica·Željka SavićLudovico Abenavoli
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Jan 3, 2020·European Journal of Gastroenterology & Hepatology·Tian LiuYi-Bo Zhou
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Aug 2, 2020·The American Journal of the Medical Sciences·Mahsa MehrdadMohammad Hassan Eftekhari

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