Severe zinc responsive dermatosis in a litter of Pharaoh Hounds

Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
Gregory A Campbell, Dennis Crow

Abstract

A litter of 3-month-old Pharaoh Hound puppies presented to the referring veterinarian with severe generalized erythematous-crusted papules with pruritus, accompanied by exfoliation and erythema of footpads, inappetence, lethargy, and retarded growth. Three of 5 puppies (2 male and 1 female) were affected. Representative areas were biopsied from 1 affected male puppy and were routinely processed. Histologically, there was marked epidermal hyperplasia with a disorganized appearance of the epidermis and massive parakeratotic hyperkeratosis, compatible with zinc-responsive dermatosis. Low serum zinc concentrations were documented, and the affected animals partially responded to intravenous zinc supplementation but did not respond to oral supplementation. One male puppy died as a result of unrelated causes and was necropsied. The remaining 4 puppies were followed over 2 years. Growth was stunted, and enamel hypoplasia of permanent dentition developed compared with unaffected littermates. Intravenous zinc supplementation at 3-4 week intervals was required to prevent further skin lesion development. One dog died at 3 years of age of renal failure.

References

Jan 1, 1979·The British Journal of Dermatology·N Danbolt
Jan 1, 1980·International Journal of Dermatology·G A Kunkle
Dec 6, 2000·The Journal of Small Animal Practice·N A McEwanI A McCandlish
May 22, 2001·Veterinary Dermatology·S D WhiteC Outerbridge
Aug 19, 2007·Molecular Genetics and Metabolism·Arthur GriderMargret L Casal
Nov 22, 2008·Biochemical Society Transactions·Glen K Andrews
Apr 17, 2009·Human Mutation·Sébastien SchmittStéphane Bézieau

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Citations

Nov 28, 2012·The Veterinary Clinics of North America. Small Animal Practice·Catherine A Outerbridge
Sep 14, 2016·Veterinary Dermatology·Fiona F LeeElizabeth A Mauldin

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Methods Mentioned

BETA
biopsies
biopsy

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