Severe/uncontrolled asthma and overall survival in atopic patients with eosinophilic granulomatosis with polyangiitis

Respiratory Medicine
Alvise BertiKarina A Keogh

Abstract

Although asthma, rhinitis/rhinosinusitis and peripheral eosinophilia are present in virtually all patients with eosinophilic granulomatosis with polyangiitis (EGPA), the role of atopy in these patients is not well defined. To clarify the role of atopy in patients affected with EGPA. Clinical, laboratory and standard spirometry data have been abstracted from medical records. Only patients who underwent skin and/or specific IgE testing for common aeroallergens before the vasculitic phase were included. Overall, 33.5% (63) of our patients underwent skin and/or specific IgE testing to aeroallergens. Atopy related to aeroallergens was confirmed in 22.3% (two-third of those tested), and was associated with more severe/uncontrolled asthma (p < 0.001), including a greater use of oral glucocorticoids for respiratory manifestations the year before the diagnosis of EGPA (p = 0.013). Atopic patients with EGPA had higher total serum IgE levels and less renal disease at EGPA diagnosis compared to non-atopic patients (p < 0.05). Among atopic patients, the majority had multiple sensitizations (76%); dust mite and grass pollen were the most common respiratory allergens identified. The number of allergens did not correlate with peripheral eosino...Continue Reading

Citations

Jan 4, 2020·Clinical Rheumatology·Marta Casal MouraMisbah Baqir
Dec 4, 2020·Journal of Clinical Medicine·Takeo IsozakiTsuyoshi Kasama
Jul 11, 2020·La Presse médicale·Goethe SacotoDivi Cornec

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