Severity and multiplicity of microvascular complications are associated with QT interval prolongation in patients with type 2 diabetes

Journal of Diabetes Investigation
Shunsuke KobayashiHitoshi Sugihara

Abstract

A prolonged QT interval plays a causal role in life-threatening arrhythmia, and becomes a risk factor for sudden cardiac death. Here, we assessed the association between microvascular complications and the QT interval in patients with type 2 diabetes. Patients with type 2 diabetes (n = 219) admitted to Nippon Medical School Hospital (Tokyo, Japan) for glycemic control were enrolled. QT interval was measured manually in lead II on the electrocardiogram, and corrected for heart rate using Bazett's formula (QTc). Diabetic neuropathy, retinopathy and nephropathy were assessed by neuropathic symptoms or Achilles tendon reflex, ophthalmoscopy and urinary albumin excretion, respectively. In univariate analyses, female sex (P = 0.025), duration of type 2 diabetes (P = 0.041), body mass index (P = 0.0008), systolic blood pressure (P = 0.0011) and receiving insulin therapy (P < 0.0001) were positively associated with QTc. Patients with each of the three microvascular complications had longer QTc than those without: neuropathy (P = 0.0005), retinopathy (P = 0.0019) and nephropathy (P = 0.0001). As retinopathy or nephropathy progressed, QTc became longer (P < 0.001 and P < 0.001 for trend in retinopathy and nephropathy, respectively). Furt...Continue Reading

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Citations

Oct 28, 2018·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Peng LiuGuoliang Li
Dec 28, 2019·Renal Failure·Peng LiuGuoliang Li
Nov 20, 2019·Journal of Clinical Pharmacology·Munveer ThindJ Rick Turner
Jun 17, 2020·Molecular & Cellular Proteomics : MCP·Sung-Soo ParkJean-François Rual
Jul 16, 2020·Annual Review of Pharmacology and Toxicology·Emely ThompsonDavid Fedida
Dec 15, 2020·Journal of Diabetes Investigation·Kuan-Yu LinTien-Jyun Chang
Jan 17, 2021·Molecular & Cellular Proteomics : MCP·Sung-Soo ParkJean-François Rual
Jun 10, 2021·Therapeutic Advances in Endocrinology and Metabolism·Shunsuke KobayashiHitoshi Sugihara
Dec 22, 2021·Journal of Diabetes Investigation·Ai-Jun JiangQian Li

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