Severity assessment of intracranial large artery stenosis by pressure gradient measurements: A feasibility study

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
Yun-Fei HanXin-feng Liu

Abstract

Fractional flow reserve (FFR)-guided revascularization strategy is popular in coronary intervention. However, the feasibility of assessing stenotic severity in intracranial large arteries using pressure gradient measurements still remains unclear. Between March 2013 and May 2014, 12 consecutive patients with intracranial large artery stenosis (including intracranial internal carotid artery, middle cerebral M1 segment, intracranial vertebral artery, and basilar artery) were enrolled in this study. The trans-stenotic pressure gradient was measured before and/or after percutaneous transluminal angioplasty and stenting (PTAS), and was then compared with percent diameter stenosis. A Pd /Pa cut-off of ≤0.70 was used to guide stenting of hemodynamically significant stenoses. The device-related and procedure-related serious adverse events and recurrent cerebral ischemic events were recorded. The target vessel could be reached in all cases. No technical complications occurred due to the specific study protocol. Excellent pressure signals were obtained in all patients. For seven patients who performed PTAS, the mean pre-procedural pressure gradient decreased from 59.0 ± 17.2 to 13.3 ± 13.6 mm Hg after the procedure (P < 0.01). Only one p...Continue Reading

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Aug 22, 2015·PloS One·Jason S NaftulinSydney S Cash
Jan 10, 2017·International Journal of Stroke : Official Journal of the International Stroke Society·Yuehua PuLiping Liu
Feb 6, 2017·Circulation Research·Chirantan Banerjee, Marc I Chimowitz
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Jan 24, 2020·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Da-Wei ChenWei-Qing Zhang
Feb 19, 2020·Journal of Neurointerventional Surgery·Xiaohui XuXinfeng Liu
Mar 25, 2017·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Baixue JiaZhongrong Miao
Aug 26, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·David MarleviDavid A Nordsletten

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