Severity of alcohol withdrawal symptoms depends on developmental stage of Long-Evans rats.

Pharmacology, Biochemistry, and Behavior
Chun-Shiang ChungDennis E Rhoads

Abstract

To investigate alcohol dependency and the potential role of age of initial alcohol consumption, Long-Evans (LE) rats were fed an ethanol-containing liquid diet starting at postnatal (P) ages (days): P23-27 (juvenile), P35-45 (adolescent) or P65-97 (young adult). Severity of subsequent withdrawal symptoms was dependent on age when consumption began and on duration of alcohol consumption. Frequency of withdrawal seizures was highest for rats starting consumption as juveniles, intermediate for adolescents and lowest for adults. Normalized to body weight, alcohol consumption was significantly higher for adolescent and juvenile rats than for adults. Sprague-Dawley rats that began alcohol consumption as adolescents (P35) had a level of alcohol consumption identical to that of the adolescent LE rats but showed much lower frequency of withdrawal seizures when tested after 2, 3 and 5 weeks of alcohol consumption. Based on several indicators, the capacity of the juveniles to metabolize ethanol is equal to or exceeds that of adults. Recoveries from a single dose of ethanol (2.5 g ethanol/kg body weight) were faster for juvenile LE rats than adults. The rate of decline in blood ethanol concentration was identical for juvenile and adult rat...Continue Reading

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Citations

Mar 13, 2010·Current Opinion in Psychiatry·Kimberly Nixon, Justin A McClain
Jan 10, 2013·Alcoholism, Clinical and Experimental Research·Priscila F Carrara-NascimentoRosana Camarini
Mar 1, 2011·Alcoholism, Clinical and Experimental Research·Margaret BroadwaterLinda P Spear
May 13, 2014·Neuroscience and Biobehavioral Reviews·Linda Patia Spear, H Scott Swartzwelder
Apr 21, 2011·Pharmacology, Biochemistry, and Behavior·Dennis E RhoadsLucas J Rhoads
Aug 4, 2016·Neurotoxicity Research·Patrycja KleczkowskaMagdalena Bujalska-Zadrozny
Apr 9, 2016·Brazilian Dental Journal·Marcius Comparsi WagnerCassiano Kuchenbecker Rösing
Dec 10, 2014·Biomolecules & Therapeutics·Hye Jin ChaHo-Sang Jeong
Nov 19, 2013·Biomolecules & Therapeutics·Hye Jin ChaHo-Sang Jeong
Jan 24, 2017·Alcoholism, Clinical and Experimental Research·Tiffani D M Berkel, Subhash C Pandey
Aug 10, 2020·Journal of Addiction Medicine·Arantza SanvisensUNKNOWN CohRTA study
Sep 7, 2021·Alcoholism, Clinical and Experimental Research·Jennifer K MelbourneKimberly Nixon

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