Severity of atrophic gastritis related to antiparietal cell antibody and gastric carcinogenesis, including p53 mutations

Journal of Gastroenterology and Hepatology
Ayumu TaguchiHidemi Goto

Abstract

Infection with Helicobacter pylori (Hp) has been linked to atrophic gastritis, an inflammatory precursor of non-cardia gastric carcinoma. Mutations in the p53 gene are one of the most frequent genetic alterations in gastric carcinoma. In a subgroup of atrophic gastritis, antiparietal cell antibody (APCA) has been detected. This study was aimed to clarify the role of APCA in the progression of atrophic gastritis and gastric carcinogenesis, and to determine the relationship of the severity of atrophic gastritis to gastric carcinoma and to p53 mutations. In 494 control subjects and 284 gastric carcinoma patients, serum APCA was evaluated and all subjects and patients were classified into four groups using serologic markers (anti-Hp IgG antibody and pepsinogen (PG) test: positive; PG I < 70 microg/L and PG I/II ratio < 3.0) as follows: A, HP- PG-; B, HP+ PG-; C, HP+ PG+ and D, HP- PG+. p53 mutations were analyzed in 174 of 284 patients. Antiparietal cell antibody seropositivity increased from group B to D, however, no difference in its positivity was found between controls and patients. The incidence of gastric carcinoma increased from A to D, especially the intestinal subtype. The frequency of p53 gene mutations was higher in PG+ ...Continue Reading

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Citations

Feb 2, 2008·World Journal of Gastroenterology : WJG·Valeska Portela LimaSílvia Helena Barem Rabenhorst
May 14, 2009·World Journal of Gastroenterology : WJG·Feng JiYue-Liang Chen
Apr 3, 2015·Scandinavian Journal of Gastroenterology·Ilhan AfsarSelcuk Kaya
Jun 9, 2007·European Journal of Gastroenterology & Hepatology·Akihiko OguriHidemi Goto
Jan 13, 2011·The Tohoku Journal of Experimental Medicine·Ryousuke KikuchiTooru Shimosegawa

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Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

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