Severity of medial temporal atrophy and amnestic mild cognitive impairment: selecting type and number of memory tests.

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
David A LoewensteinRanjan Duara

Abstract

Medial temporal lobe atrophy (MTA) can be used as a biomarker of pathology that affects mechanisms of episodic memory. The authors compared the strength of this biomarker with performance on four memory measures and examined the influence of demographic factors including age, level of education, and primary language (English or Spanish). The Hopkins Verbal Learning Test-revised, Fuld Object Memory Evaluation (FOME), delayed memory for a story passage, and delayed visual reproduction of the Wechsler Memory Scale-revised tests were administered to 281 subjects who were diagnosed as having no cognitive impairment, mild cognitive impairment (MCI), impaired non-MCI, or dementia. MTA scores were obtained from visual ratings of the hippocampus, entorhinal cortex, and perirhinal cortex on coronal magnetic resonance imaging scans using a magnetization-prepared rapid gradient echo protocol. Age was associated with scores on all memory measures and MTA. Level of educational attainment had no influence on FOME performance but had greater associations with scores on other memory measures. In regression models, FOME scores had the strongest relationship with MTA scores, accounting for 31% of the explained variability. Among subjects with MCI...Continue Reading

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Citations

Sep 2, 2011·Journal of the International Neuropsychological Society : JINS·David J LibonDana L Penney
Mar 1, 2011·Journal of the International Neuropsychological Society : JINS·David F TateErin D Bigler
Jul 26, 2011·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Qian ShenRanjan Duara
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Nov 15, 2016·Applied Neuropsychology. Adult·Parunyou Julayanont, Doungporn Ruthirago
Aug 31, 2019·Brain Sciences·Hamed Taheri Gorji, Naima Kaabouch
Nov 15, 2019·Current Alzheimer Research·Martin VyhnálekSanto Di Nuovo
May 2, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Miriam Jocelyn RodriguezRanjan Duara
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Nov 6, 2015·Alzheimer's Research & Therapy·Brandy L CallahanUNKNOWN Alzheimer’s Disease Neuroimaging Initiative

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