PMID: 6539444Jun 1, 1984Paper

Severity of Parkinson's disease and the dosage of bromocriptine

Neurology
T A LarsenD B Calne

Abstract

In view of reports that low-dose bromocriptine (15 mg or less daily) therapy is effective in Parkinson's disease, we undertook a retrospective study of 79 patients with Parkinson's disease to evaluate factors that affect the optimal daily dose of bromocriptine in subjects whose intake of levodopa was decreased as bromocriptine was introduced. Doses of bromocriptine 15 mg or less daily were seldom therapeutic; doses of over 15 mg, up to 30 mg, were appropriate for patients with mild, early disease. Those with more severe symptoms of longer duration usually required larger doses. The optimal daily requirement of bromocriptine was correlated to the severity and duration of the illness, but not to the age of the patient.

Citations

Jan 1, 1995·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·G RansmayrM Falk
Nov 30, 2000·Current Treatment Options in Neurology·L M Shulman
May 1, 1991·Journal of Neurology, Neurosurgery, and Psychiatry·M M MouradianT N Chase
Nov 30, 1990·Journal of Chromatography·D G PhelanT T Soncrant
Jan 1, 1986·Movement Disorders : Official Journal of the Movement Disorder Society·D B Calne, U K Rinne
Jan 1, 1987·Movement Disorders : Official Journal of the Movement Disorder Society·W J WeinerJ Berger
Aug 1, 1985·Acta Neurologica Scandinavica·Y ToyokuraH Ito
Apr 1, 1987·Medicinal Research Reviews·H RoehrichM S Gold
Aug 1, 1987·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·M Beaulieu

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