Severity of periodontal disease correlates to inflammatory systemic status and independently predicts the presence and angiographic extent of stable coronary artery disease

Journal of Internal Medicine
N AmabileF Paganelli

Abstract

Periodontal disease (PD) has been recognized as a risk factor for systemic diseases, but its involvement in the pathogenesis of coronary artery disease (CAD) remains debated. We sought to evaluate the potential relations between severity of the PD, inflammatory response and angiographic lesions extent in patients with stable CAD. A total of 131 subjects referred to our centre for coronary angiography were evaluated for presence and extension of CAD, then divided into two groups, one with presence of lesions (cases, n = 85) and other one with absence of lesions (controls, n = 46). Mean periodontal pocket depth (PPkD), high sensitivity C reactive protein (hs-CRP), serum amyloid A protein (SAA) and fibrinogen levels were measured in all patients. Cases and controls did not differ according to their baseline characteristics and prevalence of traditional cardiovascular risk factors. PPkD was greater in patients with CAD than in controls (2.24 +/- 1.28 mm vs 1.50 +/- 0.93 mm, P < 0.001 by Student's t-test). Systemic inflammatory response was more pronounced in cases than in controls, with higher values of hs-CRP, SAA and fibrinogen. Furthermore, PPkD values correlated with hs-CRP (r = 0.80, P < 0.001), SAA (r = 0.71, P < 0.001), fibr...Continue Reading

References

Aug 1, 1967·Journal of Psychosomatic Research·T H Holmes, R H Rahe
Nov 1, 1993·Atherosclerosis·K J MattilaK L Hietaniemi
Mar 13, 1993·BMJ : British Medical Journal·F DeStefanoC M Russell
Oct 1, 1996·Journal of Periodontology·J BeckS Offenbacher
Feb 1, 1997·Clinical and Experimental Immunology·J L EbersoleD E Willmann
Oct 28, 1999·American Heart Journal·J D BeckS Offenbacher
Nov 4, 2000·Journal of Periodontology·V I HaraszthyR J Genco
Jan 10, 2001·JAMA : the Journal of the American Medical Association·R J GencoJ D Beck
Feb 24, 2001·Journal of the American College of Cardiology·T H HowellW G Christen
Apr 6, 2001·Journal of Periodontology·M J KowolikG J Eckert
Oct 2, 2001·Journal of Periodontology·B NoackE De Nardin
Feb 19, 2002·Journal of the American College of Cardiology·James S ZebrackUNKNOWN Intermountain Heart Collaboration Study Group
Apr 26, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Pirkko J PussinenVeikko Salomaa
May 24, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Salomon AmarJoseph A Vita
Aug 2, 2003·Stroke; a Journal of Cerebral Circulation·Moïse DesvarieuxUNKNOWN Oral Infections and Vascular Disease Epidemiology Study (INVEST)
Aug 21, 2003·JAMA : the Journal of the American Medical Association·Daniel G Hackam, Sonia S Anand
Sep 18, 2003·Journal of Lipid Research·Pirkko J PussinenSirkka Asikainen
Dec 4, 2003·European Heart Journal·G Rutger PerssonStefan Renvert
Dec 17, 2004·The New England Journal of Medicine·Jennifer K PaiEric B Rimm
Feb 5, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Pirkko J PussinenJukka T Salonen
Feb 5, 2005·Stroke; a Journal of Cerebral Circulation·Steven P EngebretsonMoïse Desvarieux
Jun 29, 2005·Circulation·James D BeckSteven Offenbacher
Dec 22, 2005·American Heart Journal·John R ElterPhoebus N Madianos
Oct 3, 2006·The Journal of the American Dental Association·Ryan T Demmer, Moïse Desvarieux
Dec 29, 2006·Annals of the New York Academy of Sciences·Niki M Moutsopoulos, Phoebus N Madianos
Mar 3, 2007·The New England Journal of Medicine·Maurizio S TonettiJohn Deanfield
Oct 1, 1996·Journal of Periodontology·James BeckSteven Offenbacher

❮ Previous
Next ❯

Citations

Oct 20, 2011·Clinical Oral Investigations·Martin WohlfeilPeter Eickholz
May 3, 2013·Journal of Periodontology·Harvey A Schenkein, Bruno G Loos
Sep 14, 2010·Clinical Lipidology·Rachel Griffiths, Suzanne Barbour
Jan 28, 2014·Journal of Endodontics·Tatiana Hassin Rodrigues CostaAiza Leal de Almeida
Jan 26, 2010·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Arthur H FriedlanderNeal R Garrett
Dec 9, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Martin WohlfeilPeter Eickholz
Dec 6, 2012·Journal of Clinical Periodontology·Joseph J KellerHerng-Ching Lin
Oct 15, 2011·American Journal of Physical Anthropology·Sharon N Dewitte, Jelena Bekvalac
Jul 5, 2012·The British Journal of Dermatology·J J Keller, H-C Lin
Sep 13, 2012·Journal of Clinical Periodontology·Joseph J KellerHerng-Ching Lin
May 3, 2013·Journal of Clinical Periodontology·Harvey A Schenkein, Bruno G Loos
Feb 26, 2013·Journal of Clinical Periodontology·Peter EickholzMartin Wohlfeil
Nov 19, 2011·Journal of Clinical Periodontology·Kåre BuhlinPirkko J Pussinen
Oct 12, 2012·Arthritis and Rheumatism·Joseph J KellerHerng-Ching Lin
Aug 18, 2010·Periodontology 2000·Sami A ZelkhaSalomon Amar
Nov 21, 2009·American Journal of Physical Anthropology·Sharon N DeWitte, Jelena Bekvalac
Jun 21, 2014·Journal of Clinical Periodontology·Syed Akhtar H BokhariMohammad Ashfaq
Jul 7, 2009·The American Journal of Cardiology·Vincent E FriedewaldUNKNOWN Journal of Periodontology
Aug 19, 2015·International Journal of Clinical Oncology·Shiu-Dong ChungChao-Hung Chen
Apr 7, 2015·Medical Microbiology and Immunology·Susan Izadi BorujeniPeter Eickholz
Nov 13, 2014·Molecular Oral Microbiology·S Amar, M Engelke
Jul 20, 2012·Biology of Reproduction·Sergio A MachadoRomana A Nowak
Jun 4, 2010·Journal of Dental Research·S BohnstedtG J Seymour
Apr 20, 2012·Circulation·Peter B LockhartUNKNOWN American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee of the Council on Cardiovascular Di
Nov 8, 2019·Journal of Clinical Periodontology·Yun ZhangYehuan Sun
Sep 13, 2013·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Chuan-Song WuDachen Chu
Jun 25, 2020·Journal of Hypertension·Davide PietropaoliRita Del Pinto
Dec 20, 2015·Technology and Health Care : Official Journal of the European Society for Engineering and Medicine·Kisang KwonKyung-Hee Kang
Sep 28, 2014·Clinical Hemorheology and Microcirculation·Nurten SeringecNeslihan Dikmenoglu
May 10, 2020·Periodontology 2000·Harvey A SchenkeinMariano Sanz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Related Papers

The New England Journal of Medicine
M S TonettiJohn Deanfield
Arteriosclerosis, Thrombosis, and Vascular Biology
William G Haynes, Clark Stanford
© 2021 Meta ULC. All rights reserved