Severity, therapeutic, and activity tear biomarkers in dry eye disease: An analysis from a phase III clinical trial

The Ocular Surface
José Pinto-FragaItziar Fernández

Abstract

To evaluate the effect of 0.1%-fluorometholone (FML) on tear inflammatory molecule levels after 22-days treatment in dry eye disease (DED) patients exposed to an adverse controlled environment (ACE), identifying different biomarkers. Analysis of a double-masked randomized clinical trial. Forty-one DED patients received 4-drops daily of topical FML (FML-group) or polyvinyl-alcohol (PA-group) for 22 days. At day 21, patients were exposed to an ACE. Tear samples were collected at V1 (baseline), V2 (pre-ACE), V3 (post-2-h-ACE) and V4 (24-h post-ACE). Concentrations of 18 molecules (EGF, IFN-γ, TNF-α, IL-1β, IL-1RA, IL-2, IL-4, IL-6, IL-8/CXCL8, IL-10, IL-12, IL-13, IL-17A, IP-10/CXCL10, MCP-1/CCL2, MIP-1α/CCL3, RANTES/CCL5 and MMP-9) were analyzed. Similarities among patients in molecule concentrations at V1 were evaluated. A linear-mixed effect model analyzed the influence of different variables on concentrations changes. Multidimensional scaling (MDS) divided patients into two groups based on differences in EGF, IFN-γ, IL-8/CXCL8, RANTES/CCL5, and MMP-9 levels at V1. Groups had different clinical severities based on Schirmer test and conjunctival and corneal staining. IL-1RA, IL-2, and TNF-α were differentially affected by time, ...Continue Reading

Citations

Aug 11, 2018·Ocular Immunology and Inflammation·Antonio Abengózar-VelaMaría Jesús González-García
Jul 18, 2018·Current Opinion in Allergy and Clinical Immunology·Edoardo VillaniPaolo Nucci
Jan 24, 2019·Pharmaceutical Research·Mitalee TamhaneVeena Viswanath
Dec 5, 2019·Investigative Ophthalmology & Visual Science·Yong Woo JiHyung Keun Lee
Sep 17, 2020·Scientific Reports·Seung Pil BangJong Hwa Jun
Jan 5, 2021·Journal of Toxicology and Environmental Health. Part a·Jung Dae LeeKyu-Bong Kim
Mar 10, 2021·Bone Marrow Transplantation·Alexandra A PietraszkiewiczRachel J Bishop
Oct 5, 2020·Experimental Eye Research·Y Wei, P A Asbell
May 29, 2021·Experimental Eye Research·Nikhil G MenonTannin A Schmidt
Aug 28, 2021·Diagnostics·Pilar CañadasMargarita Calonge
Oct 11, 2020·Experimental Eye Research·Stephen C Pflugfelder, Michael E Stern
Dec 25, 2021·Frontiers in Pharmacology·Nabangshu DasAntoine Dufour

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