Sevoflurane attenuates ventilator‑induced lung injury by regulating c‑PLA2 expression

Molecular Medicine Reports
Yong YangRui Liu

Abstract

The aim of the present study was to investigate the potential role of club cell secretory protein (CCSP), an endogenous modulator, in reducing pulmonary inflammation induced by sevoflurane following one‑lung ventilation (OLV). Healthy Japanese white rabbits were randomly assigned to six groups: Sham‑operated group (group S); respiratory management of OLV group (group O); OLV + sevoflurane treated group (group OF), club cells exfoliated + sham‑operated group (group NA), club cells exfoliated + OLV group (group NAO); and club cells exfoliated + OLV + sevoflurane treated group (group NAOF). At the end of the experimental observation, all animals in the different groups were sacrificed and lung injury was evaluated according to the lung wet/dry weight ratio and histological scoring system. Lung homogenates were harvested to detect the mRNA and protein expression of cytosolic phospholipase A2 (c‑PLA2) and CCSP. The content of arachidonic acid was measured using an ELISA. Following OLV treatment, c‑PLA2 expression was increased, CCSP expression was decreased and lung injury scores were significantly increased. Sevoflurane inhalation in the OLV‑treated group induced an upregulation of CCSP and a downregulation of c‑PLA2 expression. In...Continue Reading

References

Apr 26, 2000·The European Respiratory Journal·P Bauer
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Mar 2, 2002·Journal of Biochemistry·Makoto Murakami, Ichiro Kudo
Mar 26, 2004·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Christina C Leslie
Dec 21, 2004·Journal of Applied Physiology·Sawako YoshikawaJames C Parker
Apr 11, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Gye Young Park, John W Christman
Oct 22, 2008·Cardiovascular Drugs and Therapy·John E Burke, Edward A Dennis
Nov 18, 2008·Journal of Lipid Research·John E Burke, Edward A Dennis
Nov 27, 2008·Clinical and Experimental Immunology·M SteurerB Beck-Schimmer
Jan 21, 2009·Critical Care : the Official Journal of the Critical Care Forum·Esther K WolthuisMarcus J Schultz
Mar 21, 2009·Neurological Research·Gerald A MatchettJohn H Zhang
Jul 7, 2009·Biochimica Et Biophysica Acta·Eirini KitsiouliMarilena E Lekka
Sep 15, 2009·The International Journal of Biochemistry & Cell Biology·Susan D Reynolds, Alvin M Malkinson
Nov 18, 2009·Critical Care : the Official Journal of the Critical Care Forum·Maria A HegemanPieter M Cobelens
Dec 17, 2009·Journal of Cardiothoracic and Vascular Anesthesia·Alf KozianGöran Hedenstierna
Dec 22, 2009·Expert Opinion on Therapeutic Patents·Victoria Magrioti, George Kokotos
Aug 28, 2010·American Journal of Nephrology·H Y KongS S Zheng
Dec 22, 2010·British Journal of Anaesthesia·B Kilpatrick, P Slinger
Dec 14, 2012·Current Opinion in Anaesthesiology·Giorgio Della Rocca, Cecilia Coccia
Jan 16, 2013·Asian Pacific Journal of Tropical Medicine·Shu-Ye SongXiu-Qin Yue
Apr 5, 2013·Journal of Translational Medicine·Raquel Rodríguez-GonzálezJulián Álvarez
Jan 21, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Chuen-Mao YangChih-Kai Hsu
Nov 18, 2014·Respirology : Official Journal of the Asian Pacific Society of Respirology·Qi-Ying ShenRong-Yu Liu

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