PMID: 8942344Oct 1, 1996Paper

Sevoflurane degradation to compound A in anaesthesia breathing systems

British Journal of Anaesthesia
D D CunninghamR W Grabenkort

Abstract

Determination of an effective rate constant and activation energy allowed the application of steady-state theory to predict concentrations of compound A from sevoflurane concentrations, fresh gas flow rate, absorbent temperature and amount of absorbent. Studies by eight research groups were compared. Lower concentrations of compound A than predicted were observed at low flow rates, suggesting that its degradation by the absorbent is important in limiting the maximum observed concentrations in closed and low-flow breathing systems. Trial-to-trial and batch-to-batch variations in compound A concentrations were observed in model system tests of commercial and pilot-plant absorbents. Chemical modification of the absorbent with glycerol lowered concentrations of compound A, possibly by formation of a nucleophilic addition product. An ideal chemical scavenger would remain stable and non-volatile in the absorbent before irreversibly reacting with compound A to form a stable non-volatile product.

Citations

Jul 15, 2005·Best Practice & Research. Clinical Anaesthesiology·I Odin, P Feiss
May 20, 2003·Best Practice & Research. Clinical Anaesthesiology·Jan A Baum, Harvey J Woehlck
May 25, 2002·Acta Anaesthesiologica Scandinavica·H H Luttropp, A Johansson
Sep 18, 2015·F1000Research·Stefan De Hert, Anneliese Moerman
Mar 29, 2001·European Journal of Anaesthesiology·C GoetersH Van Aken
Oct 3, 2006·Current Opinion in Anaesthesiology·D H BremerichM Behne

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