PMID: 8968172Dec 1, 1996Paper

Sevoflurane depresses myocardial contractility less than halothane during induction of anesthesia in children

Anesthesiology
R S HolzmanS G Soriano

Abstract

Cardiovascular stability is an important prerequisite for any new volatile anesthetic. We compared echocardiographically derived indices of myocardial contractility during inhalation induction with sevoflurane and halothane in children. Twenty children were randomized to receive either halothane or sevoflurane for inhalation induction of anesthesia. No preoperative medications were given. Myocardial contractility was evaluated at baseline and at sevoflurane and halothane end-tidal concentrations of 1.0 minimum alveolar concentration (MAC) and 1.5 MAC. There were no differences between groups in patient age, sex, physical status, weight, or height. Equilibration times and MAC multiples of sevoflurane and halothane were comparable. Vital signs remained stable throughout the study. Left ventricular end-systolic meridional wall stress increased with halothane but remained unchanged with sevoflurane. Systemic vascular resistance decreased from baseline to 1 MAC and 1.5 MAC with sevoflurane. Halothane depressed contractility as assessed by the stress-velocity index and stress-shortening index, whereas contractility remained within normal limits with sevoflurane. Total minute stress and normalized total mechanical energy expenditure, ...Continue Reading

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Citations

Mar 15, 2005·Der Anaesthesist·Andreas Machotta
Jun 21, 2006·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Sulpicio G Soriano, Patrizia Bozza
May 15, 2012·Pediatric Surgery International·Mostafa SomriIbrahim Matter
Feb 2, 2008·Advances in Therapy·Pinar ZeynelogluMesut Sener
Jul 20, 1999·Paediatric Anaesthesia·S L LapinA M Reynolds
Jul 20, 1999·Paediatric Anaesthesia·J Holzki, F J Kretz
May 2, 2002·Paediatric Anaesthesia·Martin Jöhr
May 2, 2002·Paediatric Anaesthesia·Hiroshi OzasaYoji Saito
Jul 26, 2013·British Journal of Anaesthesia·D SchutteJ Lemson
Dec 21, 2006·Anesthesia and Analgesia·Nathalia JimenezKaren B Domino
Jul 25, 2007·Anesthesia and Analgesia·Sanjay M BhanankerJeffrey P Morray
May 13, 1999·Paediatric Anaesthesia·C L Chiu, C Y Wang
Jul 15, 2005·Best Practice & Research. Clinical Anaesthesiology·Benedikt Preckel, Jens Bolten
Jul 15, 2005·Best Practice & Research. Clinical Anaesthesiology·Martin Jöhr, Thomas M Berger
Jun 1, 2006·Current Opinion in Anaesthesiology·Charles Lee, Linda Mason
May 5, 2007·Current Opinion in Anaesthesiology·George H Meakin
Jan 7, 1998·Anesthesiology·V C Baum, B W Palmisano
Apr 9, 2009·Expert Opinion on Pharmacotherapy·Fabrice Michel, Jean-Michel Constantin
Nov 29, 2005·Anesthesiology Clinics of North America·Andrew T Costarino, John J Downes
Sep 24, 2004·Paediatric Anaesthesia·Donald SchwartzCharles Gibson
May 25, 2005·Paediatric Anaesthesia·M ChawatheT S Armstrong
Aug 4, 2006·Paediatric Anaesthesia·Leandro Gobbo BrazLídia Raquel de Carvalho
May 15, 2007·Paediatric Anaesthesia·Sonja SaudanWalid Habre
Mar 15, 2002·Anesthesiology Clinics of North America·Jeffrey P Morray

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