Sevoflurane exerts brain-protective effects against sepsis-associated encephalopathy and memory impairment through caspase 3/9 and Bax/Bcl signaling pathway in a rat model of sepsis

The Journal of International Medical Research
Nurdan BedirliAbdulkadir Bedirli

Abstract

Objective We compared the effects of sevoflurane and isoflurane on systemic inflammation, sepsis-associated encephalopathy, and memory impairment in a rat sepsis model of cecal ligation and puncture (CLP)-induced polymicrobial peritonitis. Methods Twenty-four rats were assigned to sham, CLP, CLP + sevoflurane, and CLP + isoflurane groups. At 72 hours after CLP, the rats underwent behavior tests. Serum cytokines were evaluated. Brain tissue samples were collected for determination of glutathione peroxidase (GPX), superoxide dismutase (SOD), and catalase; the wet/dry weight ratio; myeloperoxidase (MPO) and malondialdehyde (MDA); apoptotic gene release; and histologic examinations. Results The MPO level, wet/dry weight ratio, and histopathology scores were lower and the Bcl2a1 and Bcl2l2 expressions were upregulated in both the CLP + sevoflurane and CLP + isoflurane groups compared with the CLP group. The interleukin-6, interleukin-1β, MDA, and caspase 3, 8, and 9 levels were lower; the GPX, SOD, Bax, Bcl2, and Bclx levels were higher; and non-associative and aversive memory were improved in the CLP + sevoflurane group compared with the CLP + isoflurane group. Conclusion Sevoflurane decreased apoptosis and oxidative injury and imp...Continue Reading

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Citations

Aug 20, 2019·Journal of Cardiovascular Pharmacology·Jianling LiYalan Li
Dec 16, 2020·Neural Regeneration Research·Yi-An ZhanKe-Jian Qian
Jan 27, 2021·Molecular Neurobiology·Anderson Velasque CatarinaFernanda Bordignon Nunes
Nov 25, 2021·Experimental and Therapeutic Medicine·Deming XuWei Lin

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Methods Mentioned

BETA
sedation
enzyme-linked immunosorbent assay
enzyme assay
MDA
Profiler
PCR

Software Mentioned

ARRIVE
GEArray Expression Analysis Suite
AnaConDa
SPSS
SigmaStat

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