Sevoflurane for interventional neuroradiology procedures is associated with more rapid early recovery than propofol

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
Hugo E CastagniniMichael H Nathanson


Sevoflurane and propofol are both suitable for neuroanesthesia but have not previously been compared as maintenance agents for long duration (one to five hours) procedures. Using a multicentre international study protocol, 103 patients were randomized to receive either sevoflurane or propofol for maintenance of anesthesia during interventional neuroradiology procedures. After a standardized induction of anesthesia with propofol, 53 patients received sevoflurane 1 to 3% with 60% nitrous oxide (N(2)O) in oxygen (O(2)), and 50 patients received propofol 4 to 10 mg x kg(-1) x hr(-1) with 60% N(2)O in O(2). Maintenance agents were titrated against systemic arterial blood pressure (baseline mean arterial pressure +/- 20%). Recovery times, changes in sedation, pain, nausea and vomiting and psychomotor function during recovery and use of rescue medication were recorded. The group receiving sevoflurane had a more rapid recovery to spontaneous ventilation, extubation, eye opening and orientation compared to the group receiving propofol (3 vs 4 min, P = 0.01; 5 vs 6 min, P = 0.015; 7 vs 10 min, P < 0.001; 13 vs 17 min, P = 0.028; respectively). Sedation, pain, nausea and vomiting, and psychomotor function scores were similar in the two gr...Continue Reading


Oct 1, 1995·Anesthesia and Analgesia·B FredmanP F White
Mar 3, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·N NathanP Feiss
Apr 25, 2000·Journal of Neurosurgical Anesthesiology·C M Duffy, B F Matta

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