PMID: 8968193Dec 1, 1996Paper

Sevoflurane inhibits human platelet aggregation and thromboxane A2 formation, possibly by suppression of cyclooxygenase activity

Anesthesiology
H HirakataK Mori

Abstract

Halothane increases bleeding time and suppresses platelet aggregation in vivo and in vitro. A previous study by the authors suggests that halothane inhibits platelet aggregation by reducing thromboxane (TX) A2 receptor-binding affinity. However, no studies of the effects of sevoflurane on platelet aggregation have been published. The effects of sevoflurane, halothane, and isoflurane were examined at doses of 0.13-1.4 mM. Human platelet aggregation was induced by adenosine diphosphate, epinephrine, arachidonic acid, prostaglandin G2, and a TXA2 agonist ([+]-9, 11-epithia-11, 12-methano-TXA2, STA2) and measured by aggregometry. Platelet TXB2 levels were measured by radioimmunoassay, and the ligand-binding characteristics of the TXA2 receptors were examined by Scatchard analysis using a [3H]-labeled TXA2 receptor antagonist (5Z-7-(3-endo-([ring-4-[3H] phenyl) sulphonylamino-[2.2.1.] bicyclohept-2-exo-yl) heptenoic acid, [3H]S145). Isoflurane (0.28-0.84 mM) did not significantly affect platelet aggregation induced by adenosine diphosphate and epinephrine. Sevoflurane (0.13-0.91 mM) and halothane (0.49-1.25 mM) inhibited secondary platelet aggregation induced by adenosine diphosphate (1-10 microM) and epinephrine (1-10 microM) witho...Continue Reading

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Citations

Mar 3, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·N NathanP Feiss
Dec 17, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·H HirakataK Mori
Dec 6, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·David G SilvermanChristine S Rinder
Jan 11, 2007·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Achim G BeuleWerner Hosemann
Nov 8, 2001·Canadian Journal of Physiology and Pharmacology·R KitamuraK Fukuda
Feb 11, 1999·Anesthesia and Analgesia·I V DoğanF Y Göğüş
Jul 2, 1999·Anesthesia and Analgesia·A ParolariE Tremoli
Oct 23, 2003·Anesthesia and Analgesia·Masami SatoKazuhiko Fukuda
Jul 24, 2004·Anesthesia and Analgesia·Olivier FourcadeHugues Chap
Oct 26, 2005·Anesthesia and Analgesia·Guochang HuGeorge J Crystal
Aug 6, 2004·International Journal of Hematology·Hülya TürkanKürşat Kaptan
Oct 3, 2006·Current Opinion in Anaesthesiology·T Mizobe
Feb 26, 1998·Anesthesiology·C W HönemannM E Durieux
Mar 8, 2003·European Journal of Anaesthesiology·B HeindlB F Becker
Dec 3, 2003·European Journal of Anaesthesiology·T BerletB S Gathof
Apr 5, 2011·International Journal of Pediatric Otorhinolaryngology·Tayfun ApuhanOrhan Özturan
Mar 16, 2004·British Journal of Haematology·Pier Lorenza DordoniBianca Rocca
Sep 16, 2003·Journal of Clinical Pharmacology·Joanne BurkeScott A Waldman
Oct 6, 2015·European Journal of Pharmacology·Shuji KawamotoKazuhiko Fukuda
Sep 24, 2011·American Journal of Obstetrics and Gynecology·Chuen-Chau ChangHerng-Ching Lin
Jul 1, 2005·Current Therapeutic Research, Clinical and Experimental·Nesrin BozdoganAdem Boyaci
Dec 13, 2007·Anesthesiology·Noboru TodaYoshio Hatano
Aug 5, 2004·The Annals of Pharmacotherapy·Anna LeeAngel S C Lau
Mar 8, 2003·European Journal of Anaesthesiology·H Erolçay, L Yüceyar
Mar 8, 2003·European Journal of Anaesthesiology·R BogdanskiE Kochs
Mar 8, 2003·European Journal of Anaesthesiology·D HarmonD Lowe
Mar 8, 2003·European Journal of Anaesthesiology·M WestphalG Brodner
Mar 8, 2003·European Journal of Anaesthesiology·N AnzawaA Matsuki
Mar 8, 2003·European Journal of Anaesthesiology·O A P SantanenM P J Paloheimo
Aug 29, 2001·Anesthesia and Analgesia·L W de RossiR Rossaint

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