Sevoflurane posttreatment prevents oxidative and inflammatory injury in ventilator-induced lung injury

PloS One
Julie WagnerSimone Faller

Abstract

Mechanical ventilation is a life-saving clinical treatment but it can induce or aggravate lung injury. New therapeutic strategies, aimed at reducing the negative effects of mechanical ventilation such as excessive production of reactive oxygen species, release of pro-inflammatory cytokines, and transmigration as well as activation of neutrophil cells, are needed to improve the clinical outcome of ventilated patients. Though the inhaled anesthetic sevoflurane is known to exert organ-protective effects, little is known about the potential of sevoflurane therapy in ventilator-induced lung injury. This study focused on the effects of delayed sevoflurane application in mechanically ventilated C57BL/6N mice. Lung function, lung injury, oxidative stress, and inflammatory parameters were analyzed and compared between non-ventilated and ventilated groups with or without sevoflurane anesthesia. Mechanical ventilation led to a substantial induction of lung injury, reactive oxygen species production, pro-inflammatory cytokine release, and neutrophil influx. In contrast, sevoflurane posttreatment time dependently reduced histological signs of lung injury. Most interestingly, increased production of reactive oxygen species was clearly inhibi...Continue Reading

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Citations

Mar 6, 2019·BMC Anesthesiology·Lin ChenDaqing Ma
Aug 15, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Xiaona AnJianbo Wu
Aug 30, 2019·Current Opinion in Anaesthesiology·Jan Rossaint, Alexander Zarbock
Jul 10, 2020·Experimental Biology and Medicine·Andréa Cristiane Lopes da SilvaFrank Silva Bezerra
Nov 18, 2020·Respiratory Physiology & Neurobiology·Matheus Rocha AlmeidaFrank Silva Bezerra
Oct 23, 2020·Biomedical Journal·Shun-Chin YangTsong-Long Hwang

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Methods Mentioned

BETA
Protein Assay
ELISA
bronchoalveolar lavage

Software Mentioned

GraphPad Prism
ImageJ
SigmaPlot
GraphPad
AxioVision

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