Sevoflurane protects stunned myocardium through activation of mitochondrial ATP-sensitive potassium channels

Anesthesia and Analgesia
T HaraKoji Sumikawa

Abstract

We sought to determine the hemodynamic and cardioprotective effects of sevoflurane in canine stunned myocardium. Forty-nine dogs were allocated to one of seven groups (n = 7 for each). In six separate groups, dogs received vehicle, glibenclamide (a nonselective adenosine triphosphate-dependent potassium [K(ATP)] channel antagonist) (0.3 mg/kg IV) or 5-hydroxydecanoic acid (a mitochondrial K(ATP) channel antagonist) (5 mg/kg IV) in the presence or absence of 1 minimum alveolar concentration (1 MAC) sevoflurane. In an additional group, dogs received 1 MAC sevoflurane with hemodynamic correction. Regional myocardial contractility was evaluated with segment shortening. Measurements were made before and during 15-min ischemia and 90-min reperfusion. Recovery of segment shortening 90 min after reperfusion was significantly improved in the dogs anesthetized with sevoflurane either with or without hemodynamic correction (70.1 +/- 4.2 and 75.9 +/- 3.1% of baseline, respectively), whereas the recovery was poor in control and glibenclamide or 5-hydroxydecanoic acid pretreated dogs (33.3 +/- 4.3, 33.8 +/- 6.8, and 45.0 +/- 5.5% of baseline, respectively). Regional myocardial perfusion showed no significant difference among groups. The resu...Continue Reading

References

Dec 1, 1982·Circulation·E Braunwald, R A Kloner
May 1, 1995·Acta Anaesthesiologica Scandinavica·O TakahataH Ogawa

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Citations

Jul 20, 2002·Anesthesiology·Stefan G De HertInez E Rodrigus
Jun 3, 2008·Asian Cardiovascular & Thoracic Annals·Suraphong LorsomradeeStefan G De Hert
Nov 13, 2007·Acta Anaesthesiologica Scandinavica·M YanG Chen
Mar 1, 2005·Seminars in Cardiothoracic and Vascular Anesthesia·George DjaianiW Scott Beattie
Sep 30, 2015·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Hong-Yan XiongZhen-Xiao Jin
Apr 10, 2002·Anaesthesia·N M AgnewG N Russell
Oct 24, 2007·British Journal of Pharmacology·M-S SuleimanG D Angelini

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