Sevoflurane requirements during coloproctologic surgery: difference between two different epidural regimens

Journal of Clinical Anesthesia
Maylin KooImma Camprubi


To examine the influence of epidural morphine on the end-tidal sevoflurane concentration titrated to maintain bispectral index (BIS) values between 40 and 50. Prospective, double-blinded clinical trial. Anesthesia department of a university hospital. 40 ASA physical status I, II, and III patients scheduled for elective coloproctological surgery. Patients were randomized to receive via a thoracic epidural catheter either a) bupivacaine 0.25% (10 mL) and saline 0.9% (2 mL) as a bolus followed by an infusion of bupivacaine 0.25% (5 mL/hr) or b) bupivacaine 0.25% (10 mL) and morphine 0.1% (2 mL) as a bolus followed by an infusion of bupivacaine 0.25% plus morphine 0.025% (5 mL/hr). Anesthesia was induced with propofol, fentanyl 2 microg kg(-1) and atracurium and maintained with sevoflurane and nitrous oxide in oxygen. Sevoflurane level was titrated to maintain a BIS value between 40 and 50. After extubation, patients were asked about the presence of pain. There was no significant difference between groups of end-tidal sevoflurane concentrations at identical BIS values and hemodynamic values at any time in the study. However, the morphine group had a lower pain score level at extubation than did the plain bupivacaine group (no pain ...Continue Reading


Oct 1, 1991·British Journal of Anaesthesia·J WebsterF Carli
Jun 1, 1991·Anaesthesia·W H LiuA R Aitkenhead
Dec 1, 1987·Anesthesiology·S SjöströmA Tamsen
Sep 1, 1984·Anesthesiology·M J Cousins, L E Mather
Sep 1, 1993·British Journal of Anaesthesia·Y Hirabayashi, R Shimizu
May 1, 1993·Anesthesiology·A I McEwanP S Glass
Mar 13, 1998·British Journal of Anaesthesia·S Kiyama, J Takeda

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