Sevoflurane suppresses proliferation by upregulating microRNA-203 in breast cancer cells

Molecular Medicine Reports
Jiaying LiuBaolin Li

Abstract

Rapid proliferation is one of the critical characteristics of breast cancer. However, the underlying regulatory mechanism of breast cancer cell proliferation is largely unclear. The present study indicated that sevoflurane, one of inhalational anesthetics, could significantly suppress breast cancer cell proliferation by arresting cell cycle at G1 phase. Notably, the rescue experiment indicated that miR-203 was upregulated by sevoflurane and mediated the function of sevoflurane on suppressing the breast cancer cell proliferation. The present study indicated the function of the sevoflurane/miR-203 signaling pathway on regulating breast cancer cell proliferation. These results provide mechanistic insight into how the sevoflurane/miR-203 signaling pathway supresses proliferation of breast cancer cells, suggesting the sevoflurane/miR-203 pathway may be a potential target in the treatment of breast cancer.

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Citations

Jun 14, 2019·Journal of Cellular Biochemistry·Guangming SongTianhua Li
Mar 19, 2020·Cancer Management and Research·Yichi XuXueqiong Zhu
Sep 23, 2018·Journal of Experimental & Clinical Cancer Research : CR·Baojin WangJunming Yue
Mar 16, 2021·Frontiers in Oncology·Jiaqiang WangShaoqiang Huang
May 29, 2021·OncoTargets and Therapy·Suqing SunShimin Shan
Jul 25, 2021·International Journal of Molecular Sciences·Aida Raigon PonferradaJose Cruz Mañas

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