Sevoflurane with or without antiemetic prophylaxis of dexamethasone in spontaneously breathing patients undergoing outpatient anorectal surgery

Journal of Clinical Anesthesia
Jyh-I WuPing-Heng Tan

Abstract

To evaluate the prophylactic use of dexamethasone with sevoflurane in outpatient anorectal surgery. Randomized, controlled study. Operating room and Postanesthesia Care Unit of a general hospital. 60 adult, ASA physical status I and II outpatients undergoing anorectal surgery. Patients were randomized to receive either dexamethasone 5 mg intravenously (IV; Group D; n = 30) or an equal volume of saline (Group S; n = 30) before anesthesia induction. Anesthesia was induced with propofol 2.5 mg.kg(-1), fentanyl two microg.kg(-1), and 2% lidocaine one mg.kg(-1) followed by placement of a Laryngeal Mask Airway. Frequency of postoperative nausea and vomiting (PONV), visual analog scale (VAS) pain scores, and patient satisfaction were recorded. Frequency of PONV and VAS pain scores were significantly lower in Group D than Group S (P < 0.05). The time required for "home readiness" was significantly shorter in Group D than Group S (P < 0.05). The prophylactic administration of 5 mg dexamethasone IV can reduce the frequency of PONV, lower VAS pain scores, facilitate recovery to home readiness, and improve satisfaction in outpatients undergoing anorectal surgery.

Associated Clinical Trials

Mar 30, 2015·Peter Cataldo, MD

References

Apr 1, 1980·Gynecologic Oncology·W M RichP J DiSaia
Dec 1, 1995·Anesthesia and Analgesia·I SmithP F White
Feb 1, 1995·Journal of Clinical Anesthesia·J A Aldrete
Nov 1, 1996·Drugs·R Tavorath, P J Hesketh
Jul 17, 1998·Journal of Clinical Anesthesia·E M Tarazi, B K Philip
Dec 10, 1999·Anesthesia and Analgesia·P F White, M F Watcha
Apr 27, 2000·Anesthesia and Analgesia·P F White
May 29, 2000·The New England Journal of Medicine·UNKNOWN Italian Group for Antiemetic Research
Nov 8, 2001·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J C HuangJ J Wang
Oct 28, 2003·Annals of Surgery·Mark P Callery

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Citations

Dec 12, 2012·Anesthesia and Analgesia·Gildasio S De OliveiraRobert J McCarthy
Sep 22, 2011·Current Opinion in Anaesthesiology·M Stephen MeltonTong J Gan
Sep 9, 2015·Diseases of the Colon and Rectum·Charles A TernentUNKNOWN American Society of Colon and Rectal Surgeons
Jul 1, 2010·Expert Opinion on Pharmacotherapy·Jørgen B DahlHenrik Kehlet
Oct 20, 2020·The Cochrane Database of Systematic Reviews·Stephanie WeibelPeter Kranke
Nov 6, 2010·Current Opinion in Anaesthesiology

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