Chromosomal region 17q12-q21 is one of the best-replicated genome-wide association study (GWAS) hits and associated with childhood-onset asthma. However, the mechanism by which the genetic association is restricted to childhood-onset disease is unclear. During childhood, more boys than girls develop asthma. Therefore, we tested the hypothesis that the 17q12-q21 genetic association was sex-specific. Indeed, a TDT test showed that in the Saguenay-Lac-Saint-Jean familial collection, the 17q12-q21 association was significant among male, but not among female asthmatic subjects. We next hypothesized that the bias in the genetic association resulted from sex-specific and/or age-dependent DNA methylation at regulatory regions and determined the methylation profiles of five 17q12-q21 gene promoters using the bisulfite sequencing methylation assay. We identified a single regulatory region within the zona pellucida binding protein 2 (ZPBP2) gene, which showed statistically significant differences between males and females with respect to DNA methylation. DNA methylation also varied with age and was higher in adult males compared to boys. We have recently identified two functionally important polymorphisms, both within the ZPBP2 gene that ...Continue Reading
DNA methylation of the allergy regulatory gene interferon gamma varies by age, sex, and tissue type in asthmatics
Local genotype influences DNA methylation at two asthma-associated regions, 5q31 and 17q21, in a founder effect population
Clinical approaches towards asthma and chronic obstructive pulmonary disease based on the heterogeneity of disease pathogenesis
Exposome in IBD: recent insights in environmental factors that influence the onset and course of IBD
The use of pharmacogenomics, epigenomics, and transcriptomics to improve childhood asthma management: Where do we stand?
The interplay of DNA methylation over time with Th2 pathway genetic variants on asthma risk and temporal asthma transition
X chromosome dosage and presence of SRY shape sex-specific differences in DNA methylation at an autosomal region in human cells
Loss of the zona pellucida-binding protein 2 (Zpbp2) gene in mice impacts airway hypersensitivity and lung lipid metabolism in a sex-dependent fashion
The genetics of pubertal timing in the general population: recent advances and evidence for sex-specificity
A Genomewide Association Study Identifies Two Sex-Specific Loci, at SPTB and IZUMO3, Influencing Pediatric Bone Mineral Density at Multiple Skeletal Sites
A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other
Increased DNA methylation at the AXIN1 gene in a monozygotic twin from a pair discordant for a caudal duplication anomaly
Replication of an association between 17q21 SNPs and asthma in a French-Canadian familial collection
Relation of DNA methylation of 5'-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma
17q12-21 variants interact with smoke exposure as a risk factor for pediatric asthma but are equally associated with early-onset versus late-onset asthma in North Americans of European ancestry
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium
Methylation at global LINE-1 repeats in human blood are affected by gender but not by age or natural hormone cycles
DNA methylation in the arginase-nitric oxide synthase pathway is associated with exhaled nitric oxide in children with asthma
Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT)
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations
Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network
Interaction between genetic and epigenetic variation defines gene expression patterns at the asthma-associated locus 17q12-q21 in lymphoblastoid cell lines
Sex-specific differences in the relationship between genetic susceptibility, T cell DNA demethylation and lupus flare severity
Reproducibility and intraindividual variation over days in buccal cell DNA methylation of two asthma genes, interferon γ (IFNγ) and inducible nitric oxide synthase (iNOS)
Interaction of a 17q12 variant with both fetal and infant smoke exposure in the development of childhood asthma-like symptoms
CpG island methylator phenotype-positive tumors in the absence of MLH1 methylation constitute a distinct subset of duodenal adenocarcinomas and are associated with poor prognosis
This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.
Allergies & Environmental Factors
Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.
Allergy and Asthma
Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.