PMID: 2106346Feb 23, 1990Paper

Sex- and age-related variations in the in vitro heparin-releasable lipoprotein lipase from mononuclear leukocytes in blood

Biochimica Et Biophysica Acta
F MaehiraY Eguchi

Abstract

An in vitro heparin release of lipoprotein lipase (LPL) from whole blood, mainly from monocytes, was demonstrated by (1) the time-course of lipolytic activity with the presence of 10 U/ml heparin at 37 degrees C, (2) the distribution of LPL activity in monocyte and lymphocyte fractions, (3) an immuno-inactivation with anti-LPL immunoglobulin (IgG) and (4) responses to various compounds such as NaCl, protamine sulfate, heparin, and serum activator. The in vitro heparin-releasable LPL activity from blood correlated well with the LPL activity of postheparin plasma obtained from both normolipidemic and hyperlipidemic rabbits. Studies in humans revealed sex- and age-related variations in the in vitro heparin-releasable LPL from monocytes in the blood of 134 normal subjects and 24 hypertriglyceridemic subjects: The mean LPL activity was significantly higher in normal females over the age of 30, than in the corresponding males. In the hypertriglyceridemic group, the LPL activity was also higher in females than in males, but it was not significant. The in vitro heparin-releasable LPL activity from monocytes in blood was comparable to the LPL activity derived from adipose tissue and postheparin plasma, and thus it reflects lipoprotein m...Continue Reading

References

Dec 1, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·M SugiuraT Kuratsu
Jan 1, 1977·Journal of Electrocardiology·S SatakeT Sano
Feb 1, 1987·Biochemical Medicine and Metabolic Biology·F Maehira, I Takaesu
Jan 1, 1973·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·C Y LiL T Yam
Jul 1, 1974·Analytical Biochemistry·S C MarchP Cuatrecasas
Jan 1, 1980·Journal of Immunological Methods·F Gmelig-Meyling, T A Waldmann
Jan 1, 1980·Annual Review of Biochemistry·P Nilsson-EhleM C Schotz
Feb 1, 1982·The Journal of Clinical Investigation·A ChaitJ D Brunzell

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Citations

Oct 30, 2001·The Proceedings of the Nutrition Society·A P MoloneyD J Troy
Aug 31, 1999·The Proceedings of the Nutrition Society·J D WoodP R Sheard
Dec 22, 1999·The Proceedings of the Nutrition Society·D Demeyer, M Doreau

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