Sex, ADHD symptoms, and smoking outcomes: an integrative model.

Medical Hypotheses
Elizabeth E Van VoorheesScott H Kollins

Abstract

Both females and individuals with Attention-Deficit/Hyperactivity Disorder (ADHD) have been found to be at increased risk for a range of smoking outcomes, and recent empirical findings have suggested that women with ADHD may be particularly vulnerable to nicotine dependence. On a neurobiological level, the dopamine reward processing system may be implicated in the potentially unique interaction of nicotine with sex and with ADHD status. Specifically, nicotine appears to mitigate core ADHD symptoms through interaction with the dopamine reward processing system, and ovarian hormones have been found to interact with nicotine within the dopamine reward processing system to affect neurotransmitter release and functioning. This article synthesizes data from research examining smoking in women and in individuals with ADHD to build an integrative model through which unique risk for cigarette smoking in women with ADHD can be systematically explored. Based upon this model, the following hypotheses are proposed at the intersection of each of the three variables of sex, ADHD, and smoking: (1) individuals with ADHD have altered functioning of the dopamine reward system, which diminishes their ability to efficiently form conditioned associa...Continue Reading

References

Oct 1, 1992·Psychoneuroendocrinology·S M Phillips, B B Sherwin
May 1, 1995·Addictive Behaviors·M DeBonL M Klesges
Apr 1, 1996·Current Opinion in Neurobiology·T W Robbins, B J Everitt
Jan 1, 1996·Psychopharmacology·E D LevinJ March
Jan 1, 1996·Journal of Substance Abuse·S S AllenD Nelson
Jan 1, 1997·Journal of the American Academy of Child and Adolescent Psychiatry·S MilbergerJ Jones
Mar 14, 1997·Science·W SchultzP R Montague
Aug 12, 1998·The American Journal of Psychiatry·E A SteinA S Bloom
Dec 22, 1998·Brain Research. Brain Research Reviews·K C Berridge, T E Robinson
Dec 22, 1998·Psychopharmacology·E D LevinJ E Rose
Apr 27, 1999·Nature·T W Robbins, B J Everitt
Aug 14, 1999·Journal of Clinical Child Psychology·G Tripp, B Alsop
Mar 11, 2000·Journal of Consulting and Clinical Psychology·Kenneth A PerkinsMichelle Broge
Jul 19, 2000·Pharmacology, Biochemistry, and Behavior·A J Justice, H De Wit
Aug 3, 2000·Journal of Anatomy·G W ArbuthnottJ R Wickens
Nov 10, 2000·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·S S AllenD Nelson
Nov 10, 2000·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·K A PerkinsA R Caggiula
Nov 18, 2000·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·S S AllenS Brown
Nov 22, 2000·JAMA : the Journal of the American Medical Association·K LasserD H Bor
Dec 13, 2000·Pharmacology, Biochemistry, and Behavior·J E RoseM Johnson
Feb 28, 2002·Behavioural Brain Research·Mary V Solanto
Mar 26, 2002·Archives of Sexual Behavior·Geoff SandersMarianne de Chastelaine
Sep 6, 2002·Pharmacology, Biochemistry, and Behavior·Tara L WhiteHarriet de Wit
Oct 3, 2002·Journal of Neurochemistry·R Mark Wightman, Donita L Robinson
Oct 10, 2002·Neural Networks : the Official Journal of the International Neural Network Society·John N J Reynolds, Jeffery R Wickens
Oct 18, 2002·Neuron·Wolfram Schultz
Oct 31, 2002·Psychopharmacology·Wendy J LynchMarilyn E Carroll
Dec 7, 2002·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Nora D VolkowSamuel J Gatley
Dec 10, 2002·Archives of General Psychiatry·Arthur L BrodyMurray E Jarvik
Apr 11, 2003·Journal of Attention Disorders·N D VolkowS J Gatley

❮ Previous
Next ❯

Citations

Mar 16, 2013·Psychopharmacology·Kenneth A Perkins, Joshua L Karelitz
May 21, 2013·Neuropharmacology·Laura E O'Dell, Oscar V Torres
Oct 1, 2013·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·John T MitchellScott H Kollins
May 3, 2016·Current Addiction Reports·Reagan R WetherillSharon S Allen
Dec 17, 2015·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Se-Jung ParkMihi Yang
May 31, 2013·International Journal of Cancer. Journal International Du Cancer·Yuan-Chin Amy LeeMia Hashibe
Apr 10, 2016·Behavioural Brain Research·Rodolfo J FloresLaura E O'Dell
Jan 27, 2015·Drug and Alcohol Dependence·Chien-Ti LeeBernard F Fuemmeler
Mar 13, 2015·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Rebecca L Ashare, Joseph W Kable
Jul 12, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Jodi L LukkesSusan L Andersen
Jul 28, 2016·Translational Psychiatry·R E BernardiW H Sommer
Oct 21, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Maggie M SweitzerF Joseph McClernon
Nov 20, 2018·European Psychiatry : the Journal of the Association of European Psychiatrists·J J S KooijP Asherson
Sep 29, 2017·European Psychiatry : the Journal of the Association of European Psychiatrists·C GaléraG Michel
Oct 14, 2018·European Child & Adolescent Psychiatry·Elena RaffettiMaria Rosaria Galanti
May 17, 2017·Frontiers in Psychiatry·Kenneth A PerkinsMargaret C Boldry

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.