Sex and age differences in lipid response to chronic infection with the hepatitis C virus in the United States National Health and Nutrition Examination Surveys

Journal of Viral Hepatitis
X Q LaoJeanette J McCarthy

Abstract

Low levels of serum lipids were reported in subjects chronically infected with the hepatitis C virus (HCV) and correlated with poorer clinical outcomes. Whether HCV 'hypo-lipidemia' is constant across age, sex and race has not been systematically explored. We therefore investigated the association between HCV infection and serum lipid levels in two independent National Health and Nutrition Examination Survey (NHANES) cohorts. HCV antibody status and serum lipid levels were obtained from 14 369 adults from NHANES 1999-2006 and 12 261 from NHANES III (enrolled in 1988-1994). In multivariable models, the prevalence of HCV-associated hypo-low density lipoprotein-cholesterol was highest among women >50 years of age in both NHANES 1999-2006 (OR: 10.51, 95% CI: 2.86, 38.62) and III (OR: 24.21, 95% CI: 6.17, 94.92), but among women <50 years of age, the odds ratios were 3.01 (95% CI: 1.00, 9.04) for NHANES 1999-2006 and 0.52 (95% CI: 0.14, 1.88) for III, respectively. HCV by age interaction among women was significant in both cohorts (P < 0.001 and P = 0.004, respectively). Among men, the odds ratios of HCV-associated hypo-LDL-cholesterol were 2.74 (95% CI: 1.55, 4.85) in NHANES 1999-2006 and 3.84 (95% CI: 1.66, 8.88) in III, respectiv...Continue Reading

References

Nov 1, 1996·Journal of Viral Hepatitis·Y YamakawaK Tanikawa
May 28, 1997·Clinica Chimica Acta; International Journal of Clinical Chemistry·C FabrisM Pirisi
Aug 19, 1999·The New England Journal of Medicine·M J AlterH S Margolis
Nov 4, 2000·Journal of Gastroenterology and Hepatology·G InoueM Onji
Aug 1, 1996·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Giuseppe Vittorio Luigi De SocioGiuliano Stagni
Oct 31, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Leonard B Seeff
Oct 31, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Patrick MarcellinNathalie Boyer
Jun 18, 2003·The American Journal of Gastroenterology·Jean Michel PetitPatrick Hillon
Jul 19, 2003·Journal of Clinical Gastroenterology·Mehmet KorukArif Yilmaz
Dec 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jin YeMichael Gale
Dec 19, 2003·Journal of Clinical Pharmacology·UNKNOWN Global Burden Of Hepatitis C Working Group
Nov 27, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Vincent Di MartinoThierry Poynard
Mar 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mical CampbellK Rajender Reddy
Dec 17, 2005·Journal of Hepatology·Julien MassardThierry Poynard
Dec 21, 2005·Journal of Viral Hepatitis·D SiagrisC Labropoulou-Karatza
Jan 13, 2006·Gastroenterology·Jules L Dienstag, John G McHutchison
Jan 13, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C-F JanT H-H Chen
May 17, 2006·Annals of Internal Medicine·Gregory L ArmstrongMiriam J Alter
Jul 28, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kavitha GopalAlbert D Min
Mar 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Hua HuangJin Ye
May 15, 2007·Journal of Gastroenterology and Hepatology·Michael EconomouEpameinondas Tsianos
Aug 28, 2007·Nature Cell Biology·Yusuke MiyanariKunitada Shimotohno
Nov 17, 2007·The Journal of Infectious Diseases·Chia C WangHugo R Rosen
Jul 29, 2008·Lancet·Anurag MaheshwariPaul J Thuluvath
Dec 5, 2008·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Shinichiro TadaToshifumi Hibi
Oct 27, 2009·The Journal of Infectious Diseases·Ravi JhaveriAnna Mae Diehl

❮ Previous
Next ❯

Citations

Nov 1, 2012·Seminars in Immunopathology·M F BassendineR D G Neely
Jan 24, 2012·BMC Public Health·Xiang Qian LaoIgnatius Tak Sun Yu
Mar 2, 2011·Molecular Aspects of Medicine·Maria MarinoFlavia Franconi
Jun 21, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Wen-Cheng LiChung-Hsun Chuang
Sep 21, 2013·Pediatric Hematology and Oncology·Mohammed Mostafa Al-TawilManal Hamdy El-Sayed
May 27, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·X Q LaoS M Griffiths
Feb 18, 2012·American Journal of Hypertension·Wen J MaIgnatius T S Yu
Mar 7, 2014·Journal of Oncology Practice·Jessica P HwangAnna S F Lok
Jul 16, 2015·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Laura BoemekeCatarina Bertaso Andreatta Gottschall
Apr 9, 2013·Current Neurology and Neuroscience Reports·Mariza Daras, Lisa M DeAngelis

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.