PMID: 8594306Jan 1, 1996Paper

Sex and age differences in soluble guanylate cyclase activity in human platelets

Life Sciences
T MichimataT Iriuchijima

Abstract

Soluble guanylate cyclase is a key enzyme of nitric oxide (NO)-related intracellular signal transduction in platelets. In the present study, we investigated the effects of sex and age on the enzyme activity in human platelets. Soluble guanylate cyclase activity was determined by generation of cyclic GMP in platelet cytosol. No significant differences in the basal activity of soluble guanylate cyclase were observed between in men and women, and between in young and old subjects. However, soluble guanylate cyclase activity in response to sodium nitroprusside, an exogenous NO donor, was higher in young men than in young and old women. Furthermore, the enzyme activity was lower in old than in young men, but there were no differences in female platelets between from young and old subjects. The present data suggest that NO-related signal transduction system in the platelet is affected by sex and age, which, to certain extent, contributes to different sensitivity of human platelets.

References

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Citations

Jun 30, 2007·Clinical and Experimental Pharmacology & Physiology·Virginia M MillerWhyte G Owen
Sep 2, 2020·Cancer Metastasis Reviews·Alessandra V S FariaGwenny M Fuhler
Aug 27, 2019·Frontiers in Cardiovascular Medicine·Jessica Le Blanc, Marie Lordkipanidzé
May 8, 2004·Journal of Endocrinological Investigation·C OrigliaV Martina

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