Sex and Aging: A Comparison between Two Phenoptotic Phenomena

Biochemistry. Biokhimii︠a︡
Giacinto Libertini

Abstract

Phenoptosis is a phenomenon that is genetically programmed and favored by natural selection, and that determines death or increased risk of death (fitness reduction) for the individual that manifests it. Aging, here defined as age-related progressive mortality increase in the wild, if programmed and favored by natural selection, falls within the definition of phenoptosis. Sexual reproduction (sex), as for the involved individuals determines fitness reduction and, in some species, even certain death, also falls within the definition of phenoptosis. In this review, sex and aging are analyzed as phenoptotic phenomena, and the similarities between them are investigated. In particular, from a theoretical standpoint, the genes that cause and regulate these phenomena: (i) require analyses that consider both individual and supra-individual selection because they are harmful in terms of individual selection, but advantageous (that is, favored by natural selection) in particular conditions of supra-individual selection; (ii) determine a higher velocity of and greater opportunities for evolution and, therefore, greater evolutionary potential (evolvability); (iii) are advantageous under ecological conditions of K-selection and with finite ...Continue Reading

References

Sep 21, 1979·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·T B Kirkwood, R Holliday
Nov 24, 1977·Nature·T B Kirkwood
Jul 20, 1978·Journal of Theoretical Biology·G Bell
Jul 20, 1978·Journal of Theoretical Biology·B Charlesworth
Mar 1, 1976·Journal of Theoretical Biology·J M Smith
Aug 7, 1976·Journal of Theoretical Biology·M Treisman
Oct 24, 1975·Science·S M Stanley
Sep 1, 1975·Journal of Theoretical Biology·A Zahavi
Aug 1, 1990·Biological Reviews of the Cambridge Philosophical Society·Z A Medvedev
Jun 21, 1990·Journal of Theoretical Biology·A Grafen
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L D Mueller
Apr 1, 1972·Journal of the American Geriatrics Society·D Harman
Sep 1, 1972·Journal of Theoretical Biology·G A ParkerV G Smith
May 1, 1970·Theoretical Population Biology·I Eshel, M W Feldman
Oct 19, 1968·Nature·E B Edney, R W Gill
Sep 1, 1966·Journal of Theoretical Biology·W D Hamilton
Jan 1, 1980·Experimental Gerontology·J MiquelJ E Johnson
Apr 1, 1995·Genetical Research·N H Barton
Sep 1, 1993·The Journal of Heredity·A S Kondrashov
Nov 5, 1997·The Journal of Biological Chemistry·D L Croteau, V A Bohr
Mar 31, 1998·Environmental Health Perspectives·E J Calabrese, L A Baldwin
Apr 30, 1998·Physiological Reviews·K B Beckman, B N Ames
May 6, 1999·Journal of Molecular Evolution·J Dacks, A J Roger
Apr 5, 2000·Nature·C P DoncasterS J Cox
Apr 23, 2002·Nature Reviews. Genetics·Sarah P Otto, Thomas Lenormand
Apr 27, 2002·Annals of the New York Academy of Sciences·Vladimir P Skulachev
Aug 15, 2002·Experimental Gerontology·João Pedro de Magalhães, Olivier Toussaint
Jul 8, 2003·Science of Aging Knowledge Environment : SAGE KE·Edward J Masoro
Sep 13, 2003·Journal of Applied Physiology·Brian T Weinert, Poala S Timiras
May 1, 1964·Mutation Research·H J MULLER
Jul 1, 1951·Physiological Reviews·A I LANSING
Feb 14, 2004·Medical Hypotheses·Theodore C Goldsmith
Apr 9, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Justin M J Travis
May 15, 2004·Science·Sarah P Otto, Scott L Nuismer
May 28, 2004·Nature·Aleksandra TrifunovicNils-Göran Larsson
Sep 24, 2004·Aging Cell·Dale E Bredesen
Feb 3, 2005·Genetics·N H Barton, Sarah P Otto
Mar 23, 2005·Toxicology and Applied Pharmacology·Edward J Calabrese
May 12, 2005·Mechanisms of Ageing and Development·Edward J Masoro
Jun 10, 2005·Genetics·Guillaume MartinThomas Lenormand
Nov 24, 2005·Nature Reviews. Genetics·Valter D LongoVladimir P Skulachev
Jan 10, 2006·Annals of the New York Academy of Sciences·Vladimir P Skulachev, Valter D Longo

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