Sex and evolution in trypanosomes
Abstract
Trypanosoma brucei is still the only kinetoplastid known to undergo genetic exchange, but it seems unreasonable to suppose that it evolved this process all by itself. The position of T. brucei on a molecular phylogenetic tree constructed from 18S ribosomal RNA gene sequences offers no clues to the likely existence of genetic exchange in trypanosome species other than the Salivaria, because this group of trypanosomes appears to have diverged from the rest a very long time ago. Antigenic variation is one characteristic shared by the Salivaria, which has been particularly well-studied in T. brucei. The large proportion of the genome devoted to variant antigen genes and related sequences in T. brucei, suggests a possible role for genetic exchange in enhancing the diversity of the repertoire. Alternatively, genetic exchange may counter potential excessive double-strand DNA damage brought about by the DNA rearrangements associated with antigenic variation. The remarkable biparental inheritance of organelle DNA (=kinetoplast DNA) in T. brucei is without precedent in other eukaryotes. The result of genetic exchange is to enhance the heterogeneity of the kinetoplast DNA minicircles.
References
Kinetoplast DNA and molecular karyotypes of Trypanosoma evansi and Trypanosoma equiperdum from China
Kinetoplast DNA minicircles are inherited from both parents in genetic hybrids of Trypanosoma brucei
Kinetoplast DNA minicircles are inherited from both parents in genetic crosses of Trypanosoma brucei
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African Trypanosomiasis
African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.