Sex and hormonal status influence the effects of psyllium on lipoprotein remodeling and composition

Metabolism: Clinical and Experimental
Sonia Vega-LópezMaria Luz Fernandez

Abstract

We evaluated the influence of sex and hormonal status on the effect of psyllium (PSY) supplementation on parameters of plasma lipoprotein metabolism. Twenty-four men, 23 premenopausal women, and 21 postmenopausal women (PMW) were randomly assigned to a fiber supplement (15 g PSY/d) or a control, provided via cookies, in a crossover design. Plasma lipids, insulin, apoprotein (apo) B, apo CI, apo CIII, and apo E concentrations and the composition and size of low-density lipoprotein (LDL) and very-low-density lipoprotein (VLDL) particles were measured at the end of each 30-day treatment period. Compared with control, PSY intake decreased plasma LDL cholesterol by an average of 8% (P <.0001) in men and pre- and PMW. There was a fiber-sex/hormonal status interaction on plasma triglycerides (TG) in the response to the intervention. Men had a 17% decrease in TG, while PMW had a 16% increase with PSY (P <.01). Plasma levels of apo C III, apo E, and insulin followed the same pattern as plasma TG with PSY consumption and decreased by an average of 12% in men (P <.05), but increased by 10% in PMW (P <.05). These reductions in apoproteins suggest an increased peripheral removal of TG in men, perhaps due to decreased insulin resistance, whi...Continue Reading

Citations

Jan 7, 2003·The Journal of Nutrition·Sonia Vega-LópezMaria Luz Fernandez
Jan 16, 2017·Nutrition Journal·Nicolas SauvageotMichèle Guillaume
Jan 15, 2013·Toxicology and Industrial Health·O A EsmaelT A Kumosani
Oct 4, 2003·Current Atherosclerosis Reports·Joanne R Lupton, Nancy D Turner

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