Sex and laterality differences in medial amygdala neurons and astrocytes of adult mice

The Journal of Comparative Neurology
Daniel R PfauCynthia L Jordan

Abstract

The posterodorsal aspect of the medial amygdala (MePD) in rats is sexually dimorphic, being larger and containing more and larger neurons in males than in females. It is also highly lateralized, with the right MePD larger than the left in both sexes, but with the smaller left MePD actually containing more and larger neurons than the larger right. Astrocytes are also strikingly sexually differentiated, with male-biased numbers and lateralized favoring the right in the rat MePD. However, comparable information is scant for mice where genetic tools offer greater experimental power. Hence, we examined the MePD from adult male and female C57Bl/6(J) mice. We now report that the MePD is larger in males than in females, with the MePD in males containing more astrocytes and neurons than in females. However, we did not find sex differences in astrocyte complexity or overall glial number nor effects of laterality in either measure. While the mouse MePD is generally less lateralized than in rats, we did find that the sex difference in astrocyte number is only on the right because of a significant lateralization in females, with significantly fewer astrocytes on the right than the left but only in females. A sex difference in neuronal soma ...Continue Reading

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Citations

Jun 24, 2017·Nature Reviews. Neuroscience·Margaret M McCarthyKathryn M Lenz
Jun 23, 2019·Journal of Neuroendocrinology·Justin L BollingerCara L Wellman
Dec 13, 2018·Cellular and Molecular Neurobiology·Adriana Alarcón-AguilarMina Königsberg
May 26, 2017·Aging Cell·Marianna SadagurskiRichard A Miller
Sep 26, 2019·Frontiers in Neurology·Nasim Maleki, Xiao Michelle Androulakis
Mar 17, 2021·Learning & Memory·William W TaylorBrian G Dias

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