PMID: 11326424May 1, 2001Paper

Sex and strain differences in the brush border and PAS-positive granules and giant bodies of the mouse renal S3 segment cells

Experimental Animals
A YabukiH Nishinakagawa

Abstract

We recently demonstrated sexual dimorphism in the S3 segment of the ICR mouse kidney, as differences in periodic acid Schiff (PAS) staining on the brush border and the number and size of PAS-positive granules. However, whether these sex dependent features in the S3 segment of the mouse kidney occur only in the ICR strain or are a general feature also observed in other strains is unclear. In the present study, we examined the renal S3 segment of the ICR, BALB/c, C57BL/6, C3H/He and DBA/2 mice strains, which are commonly used in laboratory experiments. PAS staining of the brush border in females of all strains was more intense than that of males, and PAS-positive granules were detected in all females. In male groups, PAS-positive granules were detected in the DBA/2 strain only, but their number was very few. In addition, PAS-positive giant bodies, larger than the nuclear size, were detected in females except those of the C57BL/6 strain. Histometrical investigation demonstrated apparent strain differences in a number of PAS-positive granules and PAS-positive giant bodies. The ultrastructural and cytochemical investigations suggest that the PAS-positive granules and PAS-positive giant bodies were multilamellar lysosomes. We propose...Continue Reading

References

Jan 1, 1985·The American Journal of Physiology·D A Wall, T Maack
Jun 1, 1995·Microscopy Research and Technique·A Gómez-PascualM Bendayan
Oct 1, 1994·Jikken dobutsu. Experimental animals·H SahataH Sakamoto
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Sep 16, 1999·The Journal of Veterinary Medical Science·A YabukiH Nishinakagawa
Feb 13, 2001·Science·B ZhaoD J Beebe

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Citations

Sep 5, 2015·Cell and Tissue Research·M S ForbesR L Chevalier
Dec 4, 2014·International Journal of Cardiology·Flavia FranconiIlaria Campesi
Jul 30, 2015·BJU International·Gregory K FontenotJoseph S Podolski
Oct 8, 2005·The Journal of Veterinary Medical Science·Ayako OkadaShusaku Suzuki
Nov 6, 2004·The Journal of Veterinary Medical Science·Michie MaedaSyusaku Suzuki
Dec 6, 2006·The Journal of Veterinary Medical Science·Nanae MurataShusaku Suzuki
May 11, 2001·The Journal of Veterinary Medical Science·A YabukiH Nishinakagawa
Jan 20, 2009·Experimental Animals·Akira YabukiShusaku Suzuki
Feb 15, 2014·Journal of Toxicologic Pathology·Mayu MutsugaYohei Miyamoto

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