Sex and strain differences in the developmental activity profile of the rat tested over clean vs home cage bedding

Developmental Psychobiology
J Buelke-SamC J Nelson

Abstract

In the first of two experiments, CD rat litters were used to characterize activity patterns obtained in a size-adjustable, single photodetector chamber. Beginning on postnatal Day 10 or 12, pups were tested repeatedly over clean bedding (C) or over bedding removed from each pup's home cage (HC). In C rats of both sexes and in HC females, short-term activity levels peaked on Day 16. However, HC males displayed an earlier and even greater elevation in activity from Day 12 to 16. This overall pattern was found in rats tested either every second or fourth day. In the second experiment, Long-Evans pups were assigned to each testing condition (C vs HC) and activity measured beginning on Day 12. Peak levels were seen in all Long-Evans rats on Day 16 and only females showed significant alterations as a function of bedding condition. When overall activity levels of the two strains were compared, significant differences were found on Days 12, 24, 30, and 120 in males, and 12, 24, and 30 in females. Significant differences between strains in activity as a function of bedding condition were found in males on Days 12, 20, 24, and 120 and in females on Days 12, 30, and 60. These data confirm the generality of a developmental hyperactivity ph...Continue Reading

References

Jul 1, 1975·Pharmacology, Biochemistry, and Behavior·B A PappasB Drew
Feb 1, 1978·Journal of Comparative and Physiological Psychology·R A Campbell, L A Raskin
May 1, 1976·Journal of Comparative and Physiological Psychology·P K Randall, B A Campbell
Feb 1, 1974·Journal of Comparative and Physiological Psychology·P D Mabry, B A Campbell
Dec 1, 1972·Journal of Comparative and Physiological Psychology·B A Campbell, P D Mabry
Jul 19, 1973·Psychopharmacologia·B A Campbell, P D Mabry
Jul 1, 1970·Physiology & Behavior·S Schapiro, M Salas
Apr 1, 1971·Journal of Comparative and Physiological Psychology·W H MoorcroftB A Campbell

❮ Previous
Next ❯

Citations

Apr 1, 1995·Physiology & Behavior·A Weller, D I Mostofsky
Sep 1, 1989·Neurotoxicology and Teratology·J Buelke-SamJ R Harmon
Feb 13, 2007·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Willem D FaberMarcy Banton
Feb 2, 2011·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·John A BiesemeierTodd Stedeford
May 1, 1985·Developmental Psychobiology·P H RuppertL W Reiter

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.