PMID: 11931222Apr 5, 2002Paper

Sex and the single chromosome

Advances in Genetics
Victoria H Meller, M I Kuroda

Abstract

Just as homology can trigger a chain of events as described in many of the chapters of this volume, sometimes a lack of homology causes a crisis of a different sort. So it is for the single X chromosome in XY males in many species. Divergent sex chromosome pairs, such as the X and Y chromosomes in mammals and in fruit flies, are thought to have evolved from homologous autosomes. During evolution, the Y chromosome has retained little coding capacity, leaving the male with reduced gene dosage for many functions encoded by the X chromosome. In this chapter we focus on dosage compensation in Drosophila, in which most X-linked genes are upregulated by a male-specific ribonucleoprotein complex. This complex is thought to recognize the X chromosome through approximately 35 dispersed chromatin entry sites and then spread in cis to dosage compensate most genes on the X chromosome.

Citations

Nov 5, 2010·Annual Review of Genetics·Vera B Kaiser, Doris Bachtrog
Jun 7, 2019·Genetics·Deborah J AndrewMichelle N Arbeitman
Jun 10, 2005·FEBS Letters·Tobias StraubPeter B Becker
Nov 25, 2005·Genesis : the Journal of Genetics and Development·Stephanie LerachKristen M Johansen
Jul 6, 2006·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Jan Larsson, Victoria H Meller
Sep 8, 2017·International Journal of Molecular Sciences·Mauro MandrioliGian Carlo Manicardi
Aug 30, 2005·Annual Review of Genomics and Human Genetics·Jennifer C ChowCarolyn J Brown
Aug 9, 2017·Molecular and Cellular Biology·Emily G KayeErica Larschan
Oct 10, 2003·Cancer Investigation·Dezhong Joshua LiaoFazlul H Sarkar
Aug 30, 2005·Mechanisms of Development·Xinxian DengVictoria H Meller
Apr 9, 2015·G3 : Genes - Genomes - Genetics·Zhen-Xia Chen, Brian Oliver
Apr 2, 2004·Development·Michelle N ArbeitmanBruce S Baker
Apr 15, 2004·Developmental Biology·Richard L Kelley
Apr 9, 2005·Mechanisms of Development·Katherine M WalstromWilliam G Kelly
Aug 8, 2006·Trends in Biochemical Sciences·Xinxian Deng, Victoria H Meller
Jul 24, 2007·Mechanisms of Ageing and Development·Phil S Hartman, Naoaki Ishii
Jan 20, 2009·Insect Biochemistry and Molecular Biology·Xingfu ZhaZhonghuai Xiang
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Jul 6, 2014·Genome Research·Yoav LubelskyDavid M MacAlpine

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