Sex-biased expression of odorant receptors in antennae and palps of the African malaria vector Anopheles gambiae.

Insect Biochemistry and Molecular Biology
Kostas Iatrou, Harald Biessmann

Abstract

At the heart of the odor recognition process in all animals are G-protein-coupled receptors, which are seven-transmembrane domain proteins that initiate G-protein-mediated signaling cascades when activated by their ligands. Odorant receptors (ORs) are a large, diverse family of proteins with some 80 members in the mosquito Anopheles gambiae. With the assumption that more sensilla on female antennae are tuned to human odors than on male antennae, comparison of specific OR mRNA levels in male and female antennae can provide an indication as to which receptors may be stimulated by host odors. We have used RT PCR and quantitative real-time PCR (qRT PCR) to investigate sex-biased expression levels of 80 A. gambiae ORs in male and female antennae and maxillary palps. On the basis of prevalence of expression in female antennae and on a strong female relative to male expression bias we identified a short list of ORs that are likely involved in host odor recognition by female mosquitoes.

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Citations

Apr 11, 2014·International Journal of Biological Sciences·Anna SchultzeJürgen Krieger
Oct 20, 2010·Cellular and Molecular Life Sciences : CMLS·Huili QiaoPaolo Pelosi
Apr 21, 2011·Journal of Insect Physiology·Julien Pelletier, Walter S Leal
Apr 22, 2015·Parasites & Vectors·Bonaventure Aman OmondiMarcelo Gustavo Lorenzo
Aug 23, 2017·Cellular and Molecular Life Sciences : CMLS·Joerg FleischerJürgen Krieger
Dec 27, 2016·Frontiers in Cellular Neuroscience·Panagiota Tsitoura, Kostas Iatrou
Feb 7, 2015·The Journal of Biological Chemistry·Panagiota TsitouraKostas Iatrou
Jul 6, 2019·Scientific Reports·A B OmondiR Ignell
Jun 10, 2015·The Journal of Experimental Biology·Bonaventure Aman OmondiRickard Ignell

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