Sex Biased Gene Expression Profiling of Human Brains at Major Developmental Stages

Scientific Reports
Lei ShiBing Su

Abstract

There are many differences in brain structure and function between males and females. However, how these differences were manifested during development and maintained through adulthood are still unclear. Here we present a time series analyses of genome-wide transcription profiles of the human brain, and we identified genes showing sex biased expression at major developmental stages (prenatal time, early childhood, puberty time and adulthood). We observed a great number of genes (>2,000 genes) showing between-sex expression divergence at all developmental stages with the greatest number (4,164 genes) at puberty time. However, there are little overlap of sex-biased genes among the major developmental stages, an indication of dynamic expression regulation of the sex-biased genes in the brain during development. Notably, the male biased genes are highly enriched for genes involved in neurological and psychiatric disorders like schizophrenia, bipolar disorder, Alzheimer's disease and autism, while no such pattern was seen for the female-biased genes, suggesting that the differences in brain disorder susceptibility between males and females are likely rooted from the sex-biased gene expression regulation during brain development. Col...Continue Reading

References

Apr 2, 2003·Virology·Naiming ZhouRoger J Pomerantz
Jun 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Daniela MarazzitiGlauco P Tocchini-Valentini
Jul 30, 2004·Molecular Biology and Evolution·Zhi ZhangJohn Parsch
Sep 17, 2004·Molecular Biology and Evolution·Asher D Cutter, Samuel Ward
Sep 29, 2004·Nature Neuroscience·Cheryl L Sisk, Douglas L Foster
May 12, 2006·Nature Reviews. Neuroscience·Larry Cahill
Jul 11, 2006·Trends in Molecular Medicine·James CoxChristopher G Woods
Aug 8, 2007·Nature Reviews. Genetics·Hans Ellegren, John Parsch
Jun 21, 2008·PLoS Genetics·Björn ReiniusElena Jazin
Aug 22, 2008·Journal of Cell Science·Jennifer L FishWieland B Huttner
Nov 26, 2008·Epigenetics : Official Journal of the DNA Methylation Society·Houng-Wei TsaiEmilie F Rissman
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
May 21, 2009·Molecular Psychiatry·C S WeickertM J Webster
Oct 24, 2009·Molecular Psychiatry·B Reinius, E Jazin
Dec 19, 2009·Nature Reviews. Neuroscience·Elena Jazin, Larry Cahill
Feb 10, 2010·Molecular Biology and Evolution·Judith E MankHans Ellegren
May 25, 2010·Human Brain Mapping·Sarah-Jayne BlakemoreRonald E Dahl
Oct 29, 2010·Genome Biology·Simon Anders, Wolfgang Huber
Nov 3, 2010·BMC Medical Genomics·Dennis P WallPeter J Tonellato
Jul 29, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Catherine Lebel, Christian Beaulieu
Aug 15, 2013·The Journal of Endocrinology·Anne-Marie O'CarrollGeorge R Pope
Oct 15, 2013·NeuroImage·Anne-Lise GoddingsSarah-Jayne Blakemore
Oct 29, 2013·Human Molecular Genetics·Hongqin XuHuiping Zhang
Nov 23, 2013·Nature Communications·Daniah TrabzuniUNKNOWN North American Brain Expression Consortium
Dec 4, 2013·Proceedings of the National Academy of Sciences of the United States of America·Madhura IngalhalikarRagini Verma
Jan 28, 2014·Nature·Menachem FromerMichael C O'Donovan
Feb 15, 2014·Molecular Biology and Evolution·Jennifer C PerryJudith E Mank
Mar 4, 2014·American Journal of Human Genetics·Sébastien JacquemontEvan E Eichler
May 29, 2014·Nature Neuroscience·Sarah E MedlandPaul M Thompson
Aug 16, 2014·Cell Reports·Daniel Ronen, Nissim Benvenisty
Sep 23, 2014·Trends in Genetics : TIG·William P GilksEdward H Morrow
Dec 18, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Georgia E HodesScott J Russo

❮ Previous
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Citations

Oct 30, 2016·Frontiers in Genetics·Benjamin T MayneClaire T Roberts
Mar 18, 2017·Scientific Reports·Mariana MaschiettoHelena Brentani
Mar 6, 2018·Current Psychiatry Reports·Sarah L FerriEdward S Brodkin
Apr 8, 2018·Biology of Sex Differences·James L J ColemanNicola J Smith
Jan 25, 2018·Annals of the New York Academy of Sciences·Devanand S Manoli, Jessica Tollkuhn
Jul 5, 2017·Psychiatry and Clinical Neurosciences·Chun WuChun-Ting Lee
Jan 29, 2020·Genes, Brain, and Behavior·Elena BrivioAlon Chen
Apr 22, 2020·Proceedings. Biological Sciences·Alex R DeCasienJames P Higham
Jan 5, 2019·Archives of Sexual Behavior·Heino F L Meyer-Bahlburg
Sep 5, 2019·Frontiers in Cellular Neuroscience·Lauren Rylaarsdam, Alicia Guemez-Gamboa
Dec 29, 2016·Briefings in Bioinformatics·Sisi GuoQinghua Cui
May 21, 2019·Wiley Interdisciplinary Reviews. Developmental Biology·Bruno Gegenhuber, Jessica Tollkuhn
Aug 28, 2020·Frontiers in Neuroscience·Marissa R KeeverSandra L Rodriguez-Zas
Nov 22, 2016·Journal of Neuroscience Research·Meng-Chuan LaiSimon Baron-Cohen
Feb 4, 2021·Endocrinology, Diabetes & Metabolism·Jasmine A FelsGiovanni Manfredi
Feb 26, 2021·Journal of Molecular Evolution·Rama S SinghShiva M Singh
Jun 9, 2021·Biological Psychiatry·Gabriëlla A M BloklandJill M Goldstein
Jun 12, 2021·Journal of Evolutionary Biology·Carrie A WhittleCassandra G Extavour

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Methods Mentioned

BETA
transcription profiling
RNA-seq
RNAseq

Software Mentioned

Excel
DAVID
DESeq R package
R package
Ensemble
Ensembl
p adjust

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