Sex-dependent alterations in the physiology of entorhinal cortex neurons in old heterozygous 3xTg-AD mice.

Biology of Sex Differences
Dany ArsenaultFrédéric Calon

Abstract

While the higher prevalence of Alzheimer's disease (AD) in women is clear, studies suggest that biological sex may also influence AD pathogenesis. However, mechanisms behind these differences are not clear. To investigate physiological differences between sexes at the cellular level in the brain, we investigated the intrinsic and synaptic properties of entorhinal cortex neurons in heterozygous 3xTg-AD mice of both sexes at the age of 20 months. This brain region was selected because of its early association with AD symptoms. First, we found physiological differences between male and female non-transgenic mice, providing indirect evidence of axonal alterations in old females. Second, we observed a transgene-dependent elevation of the firing activity, post-burst afterhyperpolarization (AHP), and spontaneous excitatory postsynaptic current (EPSC) activity, without any effect of sex. Third, the passive properties and the hyperpolarization-activated current (Ih) were altered by transgene expression only in female mice, whereas the paired-pulse ratio (PPR) of evoked EPSC was changed only in males. Fourth, both sex and transgene expression were associated with changes in action potential properties. Consistent with previous work, high...Continue Reading

References

Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Jan 1, 1993·Neuroreport·G W RobertsS M Gentleman
Jan 1, 1996·Neurology·M S MegaJ Gornbein
Nov 1, 1996·Neurobiology of Aging·B T Hyman, T Gomez-Isla
Oct 22, 2002·Nature Neuroscience·Andrea LörinczZoltan Nusser
Dec 4, 2003·Neurobiology of Aging·Salvatore OddoFrank M LaFerla
Mar 23, 2004·The Journal of Physiology·Giacomo RaffaelliEnrico Cherubini
May 21, 2005·Neuroscience Letters·Nibal AcklDorothee P Auer
May 12, 2006·Epilepsia·Joan C AmatniekYaakov Stern
Sep 1, 2006·Trends in Neurosciences·John F Disterhoft, M Matthew Oh
Oct 24, 2006·Neuroscience and Biobehavioral Reviews·L Giménez-LlortA Fernández-Teruel
May 23, 2007·Aging Cell·John F Disterhoft, M Matthew Oh
Jul 31, 2007·Neurobiology of Disease·Lani K ClintonFrank M LaFerla
Nov 30, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jenna C CarrollChristian J Pike
Sep 11, 2008·Epilepsy & Behavior : E&B·Satish C RaoRonald C Petersen
Sep 19, 2008·Proceedings of the National Academy of Sciences of the United States of America·Elizabeth A MatthewsJohn F Disterhoft
Jan 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·M Matthew OhJohn F Disterhoft
Mar 20, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rimante MinkevicieneHeikki Tanila
Apr 21, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Etienne Coutureau, Georges Di Scala
Oct 23, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ashley StackMohamed Kabbaj
Jan 1, 2010·The American Journal of Pathology·Hilda Martinez-CoriaFrank M LaFerla

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Citations

Mar 27, 2021·Mechanisms of Ageing and Development·Julie A Chowen, Luis M Garcia-Segura

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Methods Mentioned

BETA
transgenic
ELISA

Software Mentioned

JMP
pClamp
Molecular
Clampfit

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