Sex-dependent alterations of dopamine receptor and glucose transporter density in rat hypothalamus under long-term clozapine and haloperidol medication.

Brain and Behavior
Marie-Luise BouvierM von Wilmsdorff

Abstract

Sex-dependent disturbances of peripheral glucose metabolism are known complications of antipsychotic drug treatment. The influence of long-term clozapine and haloperidol medication on hypothalamus, maintaining aspects of internal body homeostasis, has not yet been completely clarified. After puberty, male and female Sprague Dawley rats were fed orally with ground pellets containing haloperidol (1 mg/kgBW/day) or clozapine (20 mg/kgBW/day) for 12 weeks. The hypothalamic protein expression of dopamine receptors D2R and D4R, melanocortin receptor MC4R, and glucose transporters Glut1 and Glut3 was examined. Glucose, glycogen, lactate, and pyruvate levels were determined, also malondialdehyde equivalents as markers of oxidative stress. D2R expression was increased in the male haloperidol and clozapine group but decreased in females medicated with clozapine. D4R expression was upregulated under clozapine medication. While females showed increased Glut1, Glut3 was elevated in both male and female clozapine-medicated animals. We found no changes of hypothalamic malondialdehyde, glycogen, and MC4R. Hypothalamic lactate was elevated in the female clozapine group. Clozapine sex-dependently affects the expression of D2R, Glut1, and Glut3. ...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Oct 1, 1983·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·E R KühnW Heyns
Jan 1, 1995·Life Sciences·M J DurcanP F Morgan
Dec 31, 1997·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·N R SwerdlowM A Geyer
Mar 31, 1999·Peptides·O RugarnC Stenfors
Oct 16, 2001·The Journal of Clinical Endocrinology and Metabolism·F BroglioE Ghigo
Feb 9, 2002·European Journal of Endocrinology·E M EgidoJ Marco
Jul 23, 2003·Pharmacology, Biochemistry, and Behavior·Donard S Dwyer, Dallas Donohoe
Aug 11, 2004·Pharmacology, Biochemistry, and Behavior·Manuela PolydoroFelipe Dal-Pizzol
Nov 9, 2004·Neuroscience Letters·Adalisa ReinkeJoão Quevedo
Jan 13, 2006·Journal of Psychopharmacology·Shona L KirkGavin P Reynolds
May 16, 2006·Life Sciences·Dave A GayleMichael G Ross
Dec 11, 2007·Biochemical and Biophysical Research Communications·Daisuke KohnoToshihiko Yada
Mar 9, 2010·Analytical Biochemistry·Isabel Romero-CalvoFermín Sánchez de Medina
Sep 15, 2010·Journal of Receptor and Signal Transduction Research·Amina S Woods
Aug 27, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Xiaoming HuJau-Shyong Hong
Nov 9, 2011·Frontiers in Molecular Neuroscience·Jean-Martin BeaulieuRaul R Gainetdinov
Mar 26, 2013·PloS One·Verόnica Contreras-ShannonConsuelo Walss-Bass
Aug 24, 2013·Trends in Neurosciences·Philipp MergenthalerAndreas Meisel
Jan 1, 2012·Molecular Metabolism·Sonja K BillesMichael A Cowley
Feb 4, 2014·Molecular Biology Reports·HaiE QuQiaoLing Zhang
Aug 12, 2014·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M von WilmsdorffW Gaebel
Dec 6, 2014·Frontiers in Cellular Neuroscience·Johann SteinerGerburg Keilhoff
Dec 30, 2014·Frontiers in Physiology·Jung D KimSabrina Diano
Apr 1, 2015·Biochemical and Biophysical Research Communications·Ekramy Elmorsy, Paul A Smith
Jan 10, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Felicitas Lopez VicchiDamasia Becu-Villalobos
Jan 27, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Kristoffer SahlholmPeter Århem
Feb 16, 2016·Journal of Neurochemistry·Sylwia ŁukasiewiczMarta Dziedzicka-Wasylewska
Jun 3, 2016·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Bruce R LawfordJason P Connor
Jun 23, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kyoji OkitaEdythe D London

❮ Previous
Next ❯

Citations

Apr 27, 2021·Frontiers in Psychiatry·Mary V Seeman

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
Protein Assay
MDA

Software Mentioned

SPSS
Gene Tools
Gene Snap

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Related Papers

The British Journal of Psychiatry : the Journal of Mental Science
R W KerwinM Launer
Hospital & Community Psychiatry
Medicina clínica
D Montero, F J de Abajo
© 2022 Meta ULC. All rights reserved