Sex-dependent correlations between the personality dimension of harm avoidance and the resting-state functional connectivity of amygdala subregions.

PloS One
Ying LiChunshui Yu

Abstract

Harm avoidance (HA) is a personality dimension involving the tendency to respond intensely to signals of aversive stimuli. Many previous neuroimaging studies have associated HA scores with the structural and functional organization of the amygdala, but none of these studies have evaluated the correlation between HA score and amygdala resting-state functional connectivity (rsFC). Moreover, the amygdala is not a homogeneous structure, and it has been divided into several structurally and functionally distinct subregions. Investigating the associations between HA score and properties of subregions of the amygdala could greatly improve our understanding of HA. In the present study, using a large sample of 291 healthy young adults, we aimed to uncover correlations between HA scores and the rsFCs of each amygdala subregion and to uncover possible sex-based differences in these correlations. We found that subregions of the amygdala showed different rsFC patterns, which contributed differently to individual HA scores. More specifically, HA scores were correlated with rsFCs between the laterobasal amygdala subregion and temporal and occipital cortices related to emotional information input, between the centromedial subregion and the fro...Continue Reading

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Citations

May 28, 2013·Brain Structure & Function·Junping WangChunshui Yu
Jan 29, 2014·Brain Research·Kai MacDonald, David Feifel
Jan 8, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Saskia Bj KochMiranda Olff
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May 20, 2017·Brain and Behavior·Benjamin ClemensUte Habel
Aug 10, 2018·Personality Neuroscience·Sebastian MarkettMartin Reuter
Jan 13, 2021·Cognitive, Affective & Behavioral Neuroscience·Víctor CostumeroCésar Ávila

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Methods Mentioned

BETA
imaging technique

Software Mentioned

Matlab
Anatomy
SPM8

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