PMID: 7376200Jan 1, 1980Paper

Sex-dependent difference in aryl hydrocarbon hydroxylase activity in mouse liver

Toxicology Letters
M WatanabeT Abe


Sex difference was observed in the aryl hydrocarbon hydroxylase (AHH) activity of liver in the C3H/He strain of mice. Treatment with estradiol showed an increase in AHH activity in gonadectomized female mice, but not in males. Testosterone, however, lowered AHH activity in both the gonadectomized male and female. Following treatment with either estradiol or testosterone in neonatal stages, AHH activity increased in males, but not in females. A sex difference was observed also in the activity of NADPH-cytochrome c reductase, which was higher in the female, but not in the levels of cytochrome P-450 and benzo[a]pyrene (BP)-induced spectral changes.


Feb 1, 1974·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L D EngelseW Misdorp


Apr 1, 1981·Journal of Steroid Biochemistry·R B Franklin, M J Vodicnik
Jan 1, 1987·Pharmacology & Toxicology·A M Laaksonen, A Julkunen

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