Sex-dependent expression of placental (P)-cadherin during mouse gonadogenesis

The Anatomical Record
L H Lin, R M DePhilip

Abstract

Placental (P)-cadherin is one of a family of cell adhesion molecules that participate in embryonic sorting and organogenesis. In previous work, P-cadherin was localized to Sertoli cells in the mouse testis as early as postnatal day 1. This early postnatal localization raised questions about when P-cadherin first appeared in the embryonic testis and whether P-cadherin was expressed differentially in the embryonic testis and ovary. The localization of P-cadherin, epithelial (E)-cadherin, and Müllerian inhibiting substance was determined in frozen sections of mouse gonads between embryonic days 10.5 and 18 using indirect immunohistochemistry. Alkaline phosphatase reactivity was used to identify germ cells. The expression of P-cadherin was traced back to the indifferent stage of gonadogenesis where uniform distribution was observed in the indifferent gonad of both sexes. However, after sexual differentiation, the expression of P-cadherin in the testis was localized to Sertoli cells in the testicular cords, while its expression in the ovary fell below detectable levels. The localization of P-cadherin in the male and female indifferent gonad is similar and cannot be used to distinguish the future testis and ovary. The localization of...Continue Reading

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Citations

Sep 14, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Alice FlemingEric Vilain
Oct 12, 2000·Developmental Biology·A Di Carlo, M De Felici
Aug 23, 2000·Biology of Reproduction·N H MachellR Farookhi
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Jul 22, 2005·Birth Defects Research. Part C, Embryo Today : Reviews·Laura L Tres, Abraham L Kierszenbaum

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