Sex-dependent expression of tenascin-C in the differentiating fetal rat testis and ovary

Differentiation; Research in Biological Diversity
J ParankoA Kaipia

Abstract

The cellular mechanisms controlling sexual differentiation of fetal gonads are poorly understood. By examining the protein and mRNA expression of tenascin-C in correlation with the immunocytochemical detection of alpha-smooth muscle actin (alpha-SMA) and basement membrane heparan sulfate proteoglycan (HSPG) we demonstrate a clear-cut sex-and development-dependent expression pattern of tenascin-C in the rat testis, ovary and mesonephros. Immunocytochemistry and in situ hybridization of tenascin-C in 15-day-pc fetal testis and ovary showed protein and mRNA accumulation within the mesenchyme of the mesogonadal connection. In addition to the male and female mesonephros, some labeling could also be seen within the testicular tunica albuginea and intraovarian mesenchymal septa. In the 17-day-pc testis abundant accumulation of tenascin mRNA and protein appeared in the tunica and mediastinum testis, but not at all in the intratesticular mesenchyme. A similar pattern was still seen in the newborns where, however, a decrease in the anti-tenascin immunoreactivity of the tunica and mediastinum could be demonstrated. In contrast to the testis, expression of tenascin in 17-day-pc ovaries was widespread within the hilus and the entire intrago...Continue Reading

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Citations

Jan 21, 2006·Molecular Reproduction and Development·Megan J WilsonPeter Koopman
May 11, 1999·Differentiation; Research in Biological Diversity·K FröjdmanI Virtanen
Dec 17, 2016·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Vlatka MartinovicKatarina Vukojevic
Jan 26, 2018·DNA and Cell Biology·Min Hee ParkSeung Tae Lee

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