Sex-Dependent Macromolecule and Nanoparticle Delivery in Experimental Brain Injury.

Tissue Engineering. Part a
Vimala N BharadwajSarah E Stabenfeldt

Abstract

The development of effective therapeutics for brain disorders is challenging, in particular, the blood-brain barrier (BBB) severely limits access of the therapeutics into the brain parenchyma. Traumatic brain injury (TBI) may lead to transient BBB permeability that affords a unique opportunity for therapeutic delivery via intravenous administration ranging from macromolecules to nanoparticles (NPs) for developing precision therapeutics. In this regard, we address critical gaps in understanding the range/size of therapeutics, delivery window(s), and moreover, the potential impact of biological factors for optimal delivery parameters. Here we show, for the first time, to the best of our knowledge, that 24-h postfocal TBI female mice exhibit a heightened macromolecular tracer and NP accumulation compared with male mice, indicating sex-dependent differences in BBB permeability. Furthermore, we report for the first time the potential to deliver NP-based therapeutics within 3 days after focal injury in both female and male mice. The delineation of injury-induced BBB permeability with respect to sex and temporal profile is essential to more accurately tailor time-dependent precision and personalized nanotherapeutics. Impact statement ...Continue Reading

References

Jan 1, 1992·Journal of Neuroscience Methods·P A StewartE Hayakawa
Sep 1, 1996·Journal of Neurosurgery·S A BaldwinS W Scheff
Oct 7, 1998·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·B Oztaş, M Kaya
Nov 24, 1999·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Z G HuangA M Buchan
Mar 22, 2001·Advanced Drug Delivery Reviews·U BickelW M Pardridge
Jun 8, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·B OztaşM Kaya
Jun 25, 2003·Experimental Neurology·S ChenN G Harris
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·William M Pardridge
Jul 19, 2008·Anesthesia and Analgesia·Kamila VagnerovaPatricia D Hurn
Dec 11, 2008·Journal of Visualized Experiments : JoVE·Ricardo Mostany, Carlos Portera-Cailliau
Jul 21, 2009·Nature Protocols·Anthony HoltmaatLinda Wilbrecht
Jun 17, 2010·Nature Reviews. Neurology·Dan ShlosbergAlon Friedman
Jul 10, 2010·Nature Reviews. Drug Discovery·Robby A Petros, Joseph M DeSimone
Apr 22, 2011·Lab Animal·Tal YardeniShelley Hoogstraten-Miller
Feb 3, 2012·Translational Stroke Research·Adam ChodobskiJoanna Szmydynger-Chodobska
Apr 28, 2012·The American Journal of Sports Medicine·Tracey CovassinAnthony Kontos
Aug 31, 2012·Science Translational Medicine·Elizabeth A NanceJustin Hanes
Dec 3, 2014·Drug Discovery Today·Keld Fosgerau, Torsten Hoffmann
Mar 11, 2015·British Journal of Pharmacology·Ila P KarvePeter J Crack
Jan 1, 2013·ISRN Biochemistry·Massimo Masserini
Jan 23, 2016·Nature Reviews. Drug Discovery·William A Banks
Jun 15, 2016·Pharmaceutical Research·Daniel BoboSimon R Corrie
Jul 23, 2016·Scientific Reports·Vimala N BharadwajSarah E Stabenfeldt
Nov 3, 2016·Journal of Neurotrauma·Zachary S BaileyBeverly A Rzigalinski
Nov 22, 2016·Journal of Neuroscience Research·Henry W CaplanSupinder S Bedi
Apr 20, 2017·Acta Neuropathologica Communications·Richard RubensteinThomas Wisniewski

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Citations

Oct 13, 2020·Advanced Healthcare Materials·Bryan D JamesJosephine B Allen
May 7, 2021·Advanced Drug Delivery Reviews·Shahriar SharifiMorteza Mahmoudi
May 22, 2021·Nature Communications·Mohammah Javad HajipourMorteza Mahmoudi
Jun 13, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jordan ToddSarah E Stabenfeldt
Jun 19, 2021·Advanced Healthcare Materials·Bryan D James, Josephine B Allen
Jun 26, 2021·Advanced Healthcare Materials·Christina Cortez-JugoFrank Caruso

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Methods Mentioned

BETA
transgenic

Software Mentioned

ImageJ
ParaVision
GraphPad Prism
GraphPad

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