Sex-dependent programming of glucose and fatty acid metabolism in mouse offspring by maternal protein restriction

Gender Medicine
Esther M E van StratenTorsten Plösch

Abstract

Nutritional conditions during fetal life influence the risk of the development of metabolic syndrome and cardiovascular diseases in adult life (metabolic programming). Impaired glucose tolerance and dysregulated fatty acid metabolism are hallmarks of metabolic syndrome. We aimed to establish a mouse model of metabolic programming focusing on the sex-specific effects of a maternal low-protein diet during gestation on glucose and lipid metabolism in the adult offspring. Pregnant C57BL/6 mice received a control or a low-protein diet (18% vs 9% casein) throughout gestation. Male and female offspring received a low-fat or a high-fat diet from 6 to 22 weeks of age. Maternal low-protein diet during gestation led to deteriorated insulin sensitivity on high-fat feeding in female offspring, as determined by biochemical and microarray analyses. Female offspring of control diet-fed dams were relatively resistant to high-fat diet-induced metabolic dysregulation. In contrast, maternal low-protein diet did not specifically affect the metabolic parameters addressed in male offspring. In males, the high-fat diet led to insulin insensitivity regardless of the diet of the dam. Our findings show that fetal malnutrition has a limited impact on male...Continue Reading

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Nov 6, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Esther M E van StratenTorsten Plösch

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Citations

Nov 2, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·N YangL A Simmons
Apr 11, 2015·Journal of Developmental Origins of Health and Disease·C J BautistaE Zambrano
Jul 10, 2012·Biochimie·Josep C Jiménez-ChillarónTorsten Plösch
Feb 4, 2014·Molecular Biology Reports·HaiE QuQiaoLing Zhang

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