Abstract
Prorenin, a precursor of renin, was measured in sera from normal subjects and type 2 diabetic patients, using a newly developed antibody-activating direct enzyme kinetic assay. Levels of prorenin were examined in relationship to diabetic microangiopathies. The levels of antibody-activating direct prorenin (AAD-PR) were approximately 1.5-fold higher than levels of prorenin measured by a conventional enzyme-activating method. AAD-PR levels were significantly higher in males than in females and in diabetic patients than in normal subjects. Moreover, AAD-PR levels were higher in diabetic patients with microalbuminuria and even higher in those with macroalbuminuria. In normoalbuminuric diabetic patients, AAD-PR levels were higher in those with retinopathy. Furthermore, a significant positive correlation was seen between the AAD-PR levels and HbA(lc) in normoalbuminuric diabetic subjects without retinopathy. Thus, the determination of circulating serum prorenin measured as AAD-PR is related to glycemia and in type 2 diabetic patients may be a risk marker of diabetic microangiopathy. More studies are necessary to determine whether AAD-PR may actually predict the development of microangiopathy.
References
May 1, 1992·Hypertension·Y F ChenS Oparil
Oct 1, 1990·The Journal of Clinical Endocrinology and Metabolism·A A FrankenM A Schalekamp
Oct 1, 1990·Diabetes Research and Clinical Practice·S AmemiyaK Kato
Jan 1, 1990·Clinical and Experimental Hypertension. Part A, Theory and Practice·F SuzukiY Nakamura
Apr 1, 1988·Hypertension·M UbedaT Quesada
Oct 1, 1986·Proteins·R A PoormanR L Heinrikson
May 30, 1985·The New England Journal of Medicine·J A LuetscherM Bryer-Ash
Apr 1, 1995·Endocrine Journal·M NaruseH Demura
Oct 1, 1994·Kidney International·D DanemanD H Osmond
Jun 1, 1993·Diabetologia·H J BangstadK F Hanssen
Sep 1, 1996·Kidney International·T J AllenG Jerums
Dec 1, 1995·Journal of Internal Medicine·S NielsenC E Mogensen
Nov 26, 1998·The British Journal of Ophthalmology·S MäkimattilaH Yki-Järvinen
Jan 20, 1999·Kidney International·N IsmailE Ritz
May 5, 1999·Bioscience, Biotechnology, and Biochemistry·F SuzukiY Nakamura
Jul 20, 1999·Kidney International·D J CampbellS L Skinner
Sep 24, 1999·Diabetologia·J DeinumM A Schalekamp
Jul 15, 2000·Diabetes Care·O KordonouriT Danne
Sep 2, 2000·Diabetes·M L CaramoriM Mauer
Mar 23, 2001·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·F ChiarelliA Verrotti
Apr 10, 2003·The Journal of Biological Chemistry·Fumiaki SuzukiKazuo Murakami
Citations
Jun 21, 2005·The British Journal of Ophthalmology·H YokotaY Ishida
Mar 10, 2012·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·M VolpeG Tocci
May 20, 2009·Life Sciences·Takashi Hayashi, Kazuo Murakami
Jun 2, 2007·Journal of Psychosomatic Research·Takashi HayashiKazuo Murakami
Feb 24, 2007·American Journal of Ophthalmology·Harumasa YokotaAkitoshi Yoshida
Mar 15, 2013·Therapeutic Advances in Cardiovascular Disease·Luis Juncos
Apr 18, 2015·Therapeutic Advances in Cardiovascular Disease·Luis I Juncos, Joaquin Caputo
Feb 19, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Harumasa YokotaAkitoshi Yoshida
Jun 17, 2005·Diabetes/metabolism Research and Reviews
Oct 18, 2014·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Harumasa YokotaAkitoshi Yoshida