Sex difference and possible relationship to microvascular complications of serum prorenin levels in type 2 diabetic patients, measured by a novel antibody-activating direct enzyme kinetic assay

Journal of Diabetes and Its Complications
Shoji KawazuY Ishida

Abstract

Prorenin, a precursor of renin, was measured in sera from normal subjects and type 2 diabetic patients, using a newly developed antibody-activating direct enzyme kinetic assay. Levels of prorenin were examined in relationship to diabetic microangiopathies. The levels of antibody-activating direct prorenin (AAD-PR) were approximately 1.5-fold higher than levels of prorenin measured by a conventional enzyme-activating method. AAD-PR levels were significantly higher in males than in females and in diabetic patients than in normal subjects. Moreover, AAD-PR levels were higher in diabetic patients with microalbuminuria and even higher in those with macroalbuminuria. In normoalbuminuric diabetic patients, AAD-PR levels were higher in those with retinopathy. Furthermore, a significant positive correlation was seen between the AAD-PR levels and HbA(lc) in normoalbuminuric diabetic subjects without retinopathy. Thus, the determination of circulating serum prorenin measured as AAD-PR is related to glycemia and in type 2 diabetic patients may be a risk marker of diabetic microangiopathy. More studies are necessary to determine whether AAD-PR may actually predict the development of microangiopathy.

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Citations

Mar 10, 2012·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·M VolpeG Tocci
Jun 2, 2007·Journal of Psychosomatic Research·Takashi HayashiKazuo Murakami
Feb 24, 2007·American Journal of Ophthalmology·Harumasa YokotaAkitoshi Yoshida
Mar 15, 2013·Therapeutic Advances in Cardiovascular Disease·Luis Juncos
Apr 18, 2015·Therapeutic Advances in Cardiovascular Disease·Luis I Juncos, Joaquin Caputo
Feb 19, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Harumasa YokotaAkitoshi Yoshida
Jun 17, 2005·Diabetes/metabolism Research and Reviews
Oct 18, 2014·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Harumasa YokotaAkitoshi Yoshida

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